Follistatin-like protein-1 is a novel proinflammatory molecule
Follistatin-like protein-1 is a novel proinflammatory molecule
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DOI：
10.4049/jimmunol.177.7.4758
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发表时间：
2006-10-01
影响因子：
4.4
通讯作者：
Hirsch, Raphael
中科院分区：
文献类型：
--
作者：
Miyamae, Takako;Marinov, Anthony D.;Hirsch, Raphael
在分析胶原诱导的关节炎的基因表达时，我们发现一个特征不佳的基因--卵泡抑素样蛋白1(FSTL-1)在关节炎早期的小鼠足爪中高表达，特别是在滑膜血管和侵蚀骨的交界处。在这项研究中，我们证明了FSTL-1是一种新的促炎分子，在炎症中具有以前未知的作用。将FSTL-1基因导入巨噬细胞和成纤维细胞，可上调IL-1β、TNF-α和IL-6等促炎细胞因子的表达。通过基因转移在小鼠足爪中过表达FSTL-1可导致严重的足肿胀和关节炎。
While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1 beta, TNF-alpha, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis.