Pilot evaluation of citalopram for the relief of hot flashes.
Pilot evaluation of citalopram for the relief of hot flashes.
复制标题
西酞普兰缓解潮热的初步评价。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
L. S. Martin
中科院分区：
文献类型：
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作者：
D. Barton;C. Loprinzi;P. Novotny;T. Shanafelt;J. Sloan;D. Wahner;T. Rummans;B. Christensen;Shaker R Dakhill;L. S. Martin
对于有乳腺癌病史但不能接受激素替代疗法的妇女来说，与过早绝经相关的症状是一个重大问题。因此，需要有效的非激素替代品来控制潮热，这是更年期最普遍的症状。先前的研究已经确定，抗抑郁药文拉法辛是治疗这种潮热的有效药物。基于具有启发性的轶事信息，我们开始评估，在一个试点试验中，抗抑郁药西酞普兰是否可能是一个很好的非激素治疗选择，以增加我们控制潮热的装备。开展了一项前瞻性先导研究，对患者进行了为期5周的研究，第一周用于建立基线，随后进行了为期4周的西酞普兰治疗。在治疗的第一周，服用西酞普兰10mg /天，在接下来的三周中，每天服用20mg /天。每日完成热闪日记，每周完成症状日记和生活质量项目，并在基线和第5周完成情绪状态概况。完成研究的可评估患者从基线到第5周平均潮热频率降低58%，平均潮热评分降低64%。完成研究的患者还报告说，他们的愤怒、紧张和抑郁情绪有所减少，情绪也有所改善。这项初步试验表明，西酞普兰可能是一种有效的非激素治疗潮热的妇女谁可以忍受。
Symptoms associated with premature menopause are a significant problem for women with a history of breast cancer who cannot take hormone replacement therapy. Thus, effective nonhormonal alternatives are needed to manage hot flashes, the most prevalent symptom of menopause. Previous studies have defined that venlafaxine, an anti-depressant, is an effective treatment for such hot flashes. Based on suggestive anecdotal information, we set out to evaluate, in a pilot trial, whether the antidepressant citalopram might be a good nonhormonal treatment option to add to our armamentarium for controlling hot flashes. A prospective pilot study was developed in which patients were studied for 5 weeks, with the first week used to establish a baseline, followed by 4 weeks of treatment with citalopram. During the first week of treatment, 10 mg/day of citalopram was taken while 20 mg/day was taken during each of the following three weeks. Hot-flash diaries were completed daily, symptom diaries and quality-of-life items were completed weekly and the Profile of Mood States was completed at baseline and at week 5. Evaluable patients who completed the study had a mean hot-flash frequency reduction of 58% and a mean hot-flash score reduction of 64% from baseline to week 5. The patients finishing the study also reported decreased anger, tension and depression, as well as improved mood. This pilot trial suggests that citalopram may be an effective non-hormonal treatment for hot flashes in women who can tolerate it.
抗抑郁药的药理学——理想药物的特征。
影响因子：
8.9
作者：
Richelson,E
通讯作者：
Richelson,E