THE MECHANICAL-BEHAVIOR OF A MAMMALIAN LUNG ALVEOLAR DUCT MODEL
THE MECHANICAL-BEHAVIOR OF A MAMMALIAN LUNG ALVEOLAR DUCT MODEL
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DOI：
10.1115/1.2794178
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发表时间：
1995-08-01
影响因子：
1.7
通讯作者：
SCHROTER, RC
中科院分区：
文献类型：
--
作者：
DENNY, E;SCHROTER, RC
使用有限元方法分析肺泡管的机械性能模型。其几何形状包括围绕纵向空气管道的截断八面体肺泡的组合。通过单独的应力应变定律建模的弹性蛋白和胶原纤维束的数量和分布基于已发布的狗数据。使用面积相关关系对气液界面的表面张力进行建模。计算出的压力-容积曲线与充满盐水和充满空气的肺的实验数据进行了很好的比较。单独的弹性蛋白和胶原纤维贡献的压力-体积曲线在形式上与用弹性蛋白酶或胶原酶处理的充满盐水的肺的行为相似。与我们之前基于单个肺泡的模型的比较表明，导管的行为更接近报告的实验数据。
A model for the mechanical properties of an alveolar duct is analyzed using the finite element method. Its geometry comprises an assemblage of truncated octahedral alveoli surrounding a longitudinal air duct. The amounts and distributions of elastin and collagen fiber bundles, modeled by separate stress-strain laws, are based upon published data for dogs. The surface tension of the air-liquid interface is modeled using an area-dependent relationship. pressure-volume curves are computed that compare well with experimental data for both saline-filled and air-filled lungs. Pressure-volume curves of the separate elastin and collagen fiber contributions are similar in form to the behavior of saline-filled lungs treated with either elastase or collagenase. A comparison with our earlier model, based upon a single alveolus, shows the duct to have a behavior closer to reported experimental data.