INFLAMMATORY CELLS IN NORMAL HUMAN FRACTURE-HEALING
INFLAMMATORY CELLS IN NORMAL HUMAN FRACTURE-HEALING
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DOI：
10.3109/17453679408995493
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发表时间：
1994-08-01
期刊：
影响因子：
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通讯作者：
MARSH, DR
中科院分区：
文献类型：
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作者：
ANDREW, JG;ANDREW, SM;MARSH, DR
我们研究了取自正常愈合的人体骨折的愈伤组织样本中的炎症细胞。使用免疫组织化学评估 T 细胞、B 细胞、巨噬细胞、HLA-DR 表达和内皮增殖。巨噬细胞从早期就存在，但后来数量减少。 T细胞最初在肉芽组织阶段被专门招募到骨折部位，但随后被排除在骨和软骨形成区域之外。正如软组织伤口愈合所提出的那样，炎症细胞可以控制和协调骨折愈合。最可能的机制是通过已知它们释放的细胞因子和生长因子。
We studied inflammatory cells in specimens of callus taken from normally healing human fractures. Using immunohistochemistry, T-cells, B-cells, macrophages, HLA-DR expression and endothelial proliferation were assessed. Macrophages were present from an early stage but became less numerous later. T-cells were initially specifically recruited into the fracture site at the stage of granulation tissue, but subsequently excluded from areas of bone and cartilage formation. Inflammatory cells may control and coordinate fracture healing as has been proposed for soft tissue wound healing. The most likely mechanism for this is by the cytokines and growth factors which they are known to release.