Pathology of the arteries in the central nervous system with special reference to their dilatation: Blood flow
Pathology of the arteries in the central nervous system with special reference to their dilatation: Blood flow
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DOI：
10.1046/j.1440-1789.2000.00274.x
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发表时间：
2000-03-01
期刊：
影响因子：
2.3
通讯作者：
Zhuang, YJ
中科院分区：
文献类型：
--
作者：
Masuda, H;Sugita, A;Zhuang, YJ
属于中枢神经系统（CNS）的动脉具有厚且单调的内弹性膜（IEL）、Willis环，并且没有通向体循环的侧支分支。这些特征表明CNS的循环是恒定的。为了了解流量如何控制中枢神经系统的动脉结构，使用8只成年雄性日本白色家兔，通过实验增加椎动脉和基底动脉的流量。单纯结扎双侧颈总动脉（结扎组，n = 4）或结扎双侧颈总动脉（结扎+AVF组，n = 4）后1周建立左颈总动脉与左颈外静脉间动静脉瘘（AVF）。血管造影显示结扎组在结扎后5周和结扎加AVF组在AVF后5周（结扎后4周）血流明显增加。椎动脉和基底动脉明显扩张和延长。组织学上，IEL的严重破坏和中膜的局灶性变薄是明显的。内皮细胞保存完好，无炎症细胞浸润。这些形态学特征与增加的血流诱导的适应性重塑一致。有人建议，恒定的流量可能会给中枢神经系统的动脉树这些形态学特征。
Arteries that belong to the central nervous system (CNS) have thick and monotonous internal elastic lamina (IEL), Willis ring, and no collateral branch to the systemic circulation. These characteristics suggest that the circulation of the CNS is constant. In order to know how flow controls the arterial configuration of the CNS, flow of the vertebral and basilar arteries was increased experimentally using eight adult male Japanese white rabbits. Flow increase was induced by the simple ligation of the bilateral common carotid arteries (ligation group, n = 4) or by the ligation of the bilateral common carotid arteries at 1 week after arteriovenous fistula (AVF) between the left common carotid artery and the left external jugular vein (ligation plus AVF group, n = 4). Cineangiography revealed distinct flow increase in the ligation group at 5 weeks after ligation and in the ligation plus AVF group at 5 weeks after AVF (4 weeks after ligation). Vertebral and basilar arteries were remarkably dilated and elongated. Histopathologically, severe disruption of the IEL and focal thinning of the media were distinct. Endothelial cells were preserved and there was no inflammatory cell infiltration. These morphological features are consistent with increased flow-induced adaptive remodeling. It is suggested that the constancy of the flow may give the arterial tree of the CNS these morphological characterizations.