Impact of body mass and body composition on circulating levels of natriuretic peptides - Results from the Dallas heart study
Impact of body mass and body composition on circulating levels of natriuretic peptides - Results from the Dallas heart study
复制标题
DOI：
10.1161/circulationaha.105.555573
复制
发表时间：
2005-10-04
期刊：
影响因子：
37.8
通讯作者：
de Lemos, JA
中科院分区：
文献类型：
--
作者：
Das, SR;Drazner, MH;de Lemos, JA
背景--高体重指数（BMI）和低B型利钠肽（BNP）水平之间的联系被认为是由脂肪组织中利钠肽清除受体（NPR-C）的表达介导的。为了探索这种关联，我们测试了两个假设：（1）据信不结合NPR-C的N-末端（NT）-proBNP与BMI无关，和（2）较低的BNP与脂肪质量的相关性比与瘦体重的相关性更密切。在来自达拉斯心脏研究的2707名受试者中，通过直接双能X线吸收测定法（DEXA）进行了身体成分和体重的测定。肥胖与低BNP之间的关系（
Background-The association between higher body mass index (BMI) and lower B-type natriuretic peptide (BNP) level isthought to be mediated by expression of the natriuretic peptide clearance receptor (NPR-C) in adipose tissue. To explore this association, we tested 2 hypotheses: ( 1) that N-terminal (NT)-proBNP, which is not believed to bind NPR-C, would not be associated with BMI and (2) that lower BNP would be more closely associated with fat mass than with lean mass.Methods and Results-Measurements of BNP, NT-proBNP, and body composition by direct dual energy x-ray absorptiometry ( DEXA) were performed in 2707 subjects from the Dallas Heart Study. The associations between obesity and low BNP (