A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
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DOI：
10.1016/s0306-4522(02)00123-9
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发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Gómez-Pinilla, F
中科院分区：
文献类型：
--
作者：
Molteni, R;Barnard, RJ;Gómez-Pinilla, F
我们研究了一种潜在的机制，通过这种机制，一种与大多数西方工业化社会中富含饱和脂肪和精制糖（HFS）的典型饮食组成相似的饮食，可以通过调节神经营养因子来影响大脑结构和功能。我们发现，学习空间记忆任务更快的动物海马中有更多的脑源性神经营养因子（BDNF） mRNA和蛋白质。两个月的HFS饮食足以降低海马BDNF水平和空间学习表现。由于BDNF对突触功能的作用，维持高脂饮食2 ~ 24个月大鼠海马中BDNF对突触可塑性作用的下游效应物与BDNF水平成比例降低。特别是，维持高脂饮食的动物表现出以下水平的降低：(i)突触素i mRNA和蛋白（总和磷酸化），这对神经递质释放很重要；（ii）环amp反应元件结合蛋白（CREB） mRNA和蛋白（总和磷酸化）；CREB是各种形式的记忆所必需的，受BDNF的调节控制；（iii）生长相关蛋白43mrna，对神经突生长、神经递质释放和学习记忆很重要。饮食相关的变化是海马特有的，因为它在记忆形成中的作用，而与神经营养蛋白家族的另一成员神经营养蛋白-3无关。我们的研究结果表明，普遍食用的饮食可以影响与BDNF功能相关的神经元和行为可塑性的关键方面。(c) 2002年ibro。Elsevier Science Ltd.出版。版权所有。
We have investigated a potential mechanism by which a diet, similar in composition to the typical diet of most industrialized western societies rich in saturated fat and refined sugar (HFS), can influence brain structure and function via regulation of neurotrophins, We show that animals that learn a spatial memory task faster have more brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus. Two months on the HFS diet were sufficient to reduce hippocampal level of BDNF and spatial learning performance. Consequent to the action of BDNF on synaptic function, downstream effectors for the action of BDNF on synaptic plasticity were reduced proportionally to BDNF levels, in the hippocampus of rats maintained on the HFS diet between 2 and 24 months. In particular, animals maintained on the HFS diet showed a decrease in levels of: (i) synapsin I mRNA and protein (total and phosphorylated), important for neurotransmitter release; (ii) cyclic AMP-response element-binding protein (CREB) mRNA and protein (total and phosphorylated); CREB is required for various forms of memory and is under regulatory control of BDNF; (iii) growth-associated protein 43 mRNA, important for neurite outgrowth, neurotransmitter release, and learning and memory. Diet-related changes were specific for the hippocampus consequent to its role in memory formation, and did not involve neurotrophin-3, another member of the neurotrophin family.Our results indicate that a popularly consumed diet can influence crucial aspects of neuronal and behavioral plasticity associated with the function of BDNF. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.