Nodal signalling in vertebrate development
Nodal signalling in vertebrate development
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DOI：
10.1038/35000126
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发表时间：
2000-01-27
期刊：
影响因子：
64.8
通讯作者：
Shen, MM
中科院分区：
文献类型：
--
作者：
Schier, AF;Shen, MM
在早期胚胎发生期间细胞之间的通讯建立了脊椎动物身体计划的基本组织。最近的工作表明，以Nodal（一种转化生长因子P相关信号）为中心的信号通路负责许多配置脊椎动物胚胎的事件。Nodal信号的活性由EGF-CFC辅因子和Lefty和Cerberus蛋白家族的拮抗剂在细胞外调节，从而精确控制中胚层和内胚层形成、前后轴的定位、神经模式和左右轴的特化。
Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor P-related signal, is responsible for many of the events that configure the vertebrate embryo. The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control of mesoderm and endoderm formation, the positioning of the anterior-posterior axis, neural patterning and left-right axis specification.