Journal of Nutritional Biochemistry Special Issue: nutritional modulation of the gut microbiome in gastrointestinal and metabolic disease.
Journal of Nutritional Biochemistry Special Issue: nutritional modulation of the gut microbiome in gastrointestinal and metabolic disease.
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DOI：
10.1016/j.jnutbio.2019.01.008
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发表时间：
2019-01
期刊：
影响因子：
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通讯作者：
J. Pierre;V. Leone;Kristina Martinez-Guryn
中科院分区：
文献类型：
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作者：
J. Pierre;V. Leone;Kristina Martinez-Guryn
《营养生物化学杂志微生物组专刊》的目标是突出一些最新的肠道微生物群研究，这些研究建立了饮食引起的肠道微生物群变化与微生物群-饮食相互作用如何影响健康和疾病之间的联系。迄今为止，许多与饮食介导的肠道生态系统改变相关的研究已经证明了微生物谱的变化与某些饮食条件或疾病状态之间的关联，但没有明确建立因果关系。虽然确定肠道微生物的因果作用仍然具有挑战性，但重要的是要关注宿主的生理相关影响。在这里，我们试图汇集旨在证明饮食介导的肠道微生物群成员和功能变化之间的因果关系的工作，特别是这些变化如何有助于，防止干扰或恢复局部和全身性疾病过程。虽然在许多情况下因果关系仍然难以捉摸，但这里概述的研究采用了移动针的工具，包括使用临床前模型，提供饮食诱导的微生物功能变化的证据，以及使用人类受试者的仔细研究设计，这些都为研究界提供了一个框架。在这期特刊中，我们总共选择了21篇文章，其中包括饮食，肠道微生物群和疾病状态之间的联系，包括代谢疾病，黄疸，炎症性肠病和其他重要的宿主过程，包括肠-脑轴，以及生长和发育。
The goal of this Journal of Nutritional Biochemistry Microbiome Special Issue is to highlight some of the latest gut microbiota research that establishes connections between dietary-induced changes in the gut microbiota and how microbiota-diet interactions influence health and disease. To date, much research related to dietary-mediated alterations in the gut ecosystem has demonstrated associations between changes in the microbial profile with certain dietary conditions or disease states without clearly establishing a causative link. While identifying the causal role of gut microbes remains challenging, it is important to focus on physiologically relevant implications for the host. Here, we have attempted to bring together work that aims to demonstrate causation between dietary-mediated changes in gut microbiota membership and function, and specifically how these changes contribute to, prevent disturbances to or restore both local and systemic disease processes. While in many cases causation still remains elusive, the studies outlined here employ tools that move the needle, including the use of preclinical models, providing evidence of diet-induced shifts in microbial function and careful study design using human subjects, which together provide a framework for the research community to build upon. In total, we have selected 21 articles in this Special Issue which feature a link between diet, the gut microbiota and disease states including metabolic diseases, jaundice, inflammatory bowel disease and other important host processes including the gut–brain axis, as well as growth and development.