Clinical assessment of scleral canal area in glaucoma using spectral domain optical coherence tomography
Clinical assessment of scleral canal area in glaucoma using spectral domain optical coherence tomography
复制标题
使用谱域光学相干断层扫描对青光眼巩膜管面积进行临床评估
DOI：
10.1016/j.ajo.2020.03.043
复制
发表时间：
2020
影响因子：
4.2
通讯作者：
and Takeshi Iwase
中科院分区：
文献类型：
--
作者：
Yu Sawada;Makoto Araie;Hitomi Shibata;Katsuyuki Murata;Makoto Ishikawa;Takeshi Yoshitomi;and Takeshi Iwase
目的应用频域光学相干断层扫描（SDOCT）技术对青光眼患者前巩膜通道（ASC）面积进行研究，设计横断面研究方法：本研究包括103例206眼青光眼患者，其中单侧青光眼33例66眼，双侧青光眼70例140眼。以视盘为中心行放射状增强深度成像SDOCT，获得每只眼的ASC开口和最大ASC面积等代表ASC面积的参数。最大ASC面积是在ASC开口和前筛板插入之间确定的ASC区域的最大横截面积。结果在单侧青光眼患者中，青光眼患者的ASC开口和最大ASC面积均明显大于非青光眼患者（P <0.001）。在双侧青光眼中，VFD较差的眼睛的这些参数明显大于VFD较好的眼睛（分别为P= 0.0080和P = 0.0018）。在青光眼患者的ASC参数的眼间差异显着大于在正常subjects.ConclusionsSignificantly更大的ASC面积首次观察到在活体人眼青光眼相比，正常的眼睛。需要进一步的纵向研究来确定ASC区域是否对青光眼的预防和治疗有用。
PurposeTo investigate anterior scleral canal (ASC) area in the eyes with glaucoma using spectral-domain optical coherence tomography (SDOCT).DesignCross-sectional study.MethodsThis study included 206 eyes of 103 patients with glaucoma, classified as 66 eyes of 33 patients with unilateral glaucoma and 140 eyes of 70 patients with bilateral glaucoma. Radial scan enhanced depth imaging SDOCT centered on the optic disc was performed, and parameters that present ASC area such as ASC opening and the largest ASC area were obtained in each eye. The largest ASC area was the largest cross-sectional area of the ASC region identified between the ASC opening and anterior lamina cribrosa insertion. These parameters were compared between eyes with and without glaucoma in unilateral glaucoma, and eyes with worse and better visual field defect (VFD) in bilateral glaucoma.ResultsIn the patients with unilateral glaucoma, ASC opening and largest ASC area were significantly larger in the eyes with glaucoma than in those without glaucoma (bothP< .001). In bilateral glaucoma, these parameters were significantly larger in the eyes with worse VFD than in those with better VFD (P= .0080 andP= .0018, respectively). Intereye differences of the ASC parameters in the glaucoma patients were significantly greater than that in the normal subjects.ConclusionsSignificantly larger ASC area was first observed in the living human eyes with glaucoma compared to the normal eyes. Further longitudinal studies are required to determine if the ASC area is useful in the prevention and treatment of glaucoma.