Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs
Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs
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DOI：
10.2307/3434557
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发表时间：
1999-08-01
影响因子：
10.4
通讯作者：
Winneke, G
中科院分区：
文献类型：
--
作者：
Brouwer, A;Longnecker, MP;Winneke, G
本文讨论了与低水平接触多氯联苯 (PCB) 造成的内分泌相关健康影响的表征相关的问题。它并不是对文献的全面回顾，而是反映了研讨会的讨论。 “表征环境暴露水平下内分泌干扰物对人类健康的影响”研讨会提供了一个论坛，讨论改进内分泌干扰物风险评估所需的方法和数据。本文概述了多氯联苯的内分泌相关（雌激素和甲状腺系统）相互作用和其他低剂量效应。关于内分泌效应的数据集包括从机械方法/和模型（基于受体、基于代谢和基于转运蛋白）以及体内模型（包括实验动物和野生动物物种的研究）获得的结果。 PCB 引起的其他低剂量效应，例如神经发育和生殖效应以及内分泌敏感肿瘤，已针对与 PCB 引起的内分泌系统改变之间可能的因果关系进行了评估。此外。介绍并严格评估了低剂量暴露及其对人群影响的研究。其中包括结论和建议清单。
This article addresses issues related to the characterization of endocrine-related health effects resulting from low-level exposures to polychlorinated biphenyis (PCBs). it is not intended to be a comprehensive review of the literature but reflects workshop discussions. "The Characterizing the Effects of Endocrine Disrupters on Human Health at Environmental Exposure Levels," workshop provided a forum to discuss the methods and data needed to improve risk assessments of endocrine disrupters. This article contains an overview of endocrine-related (estrogen and thyroid system) interactions and other low-dose effects of PCBs. The data set on endocrine effects includes results obtained from mechanistic methods/ and models (receptor based, metabolism based, and transport protein based), as well as from in vivo models, including studies with experimental animals and wildlife species. Other low-dose effects induced by PCBs, such as neurodevelopmental and reproductive effects and endocrine-sensitive tumors, have been evaluated with respect to a possible causative linkage with PCB-induced alterations in endocrine systems. In addition. studies of low-dose exposure and effects in human populations are presented and critically evaluated. A list of conclusions and recommendations is included.