Colonization of an acid resistant Kingella denitrificans in the stomach may contribute to gastric dysbiosis by Helicobacter pylori.
Colonization of an acid resistant Kingella denitrificans in the stomach may contribute to gastric dysbiosis by Helicobacter pylori.
复制标题
胃中耐酸脱氮金菌的定植可能会导致幽门螺杆菌引起的胃生态失调。
DOI：
10.1016/j.jiac.2013.09.007
复制
发表时间：
2014
影响因子：
2.2
通讯作者：
Yoshiyama H.
中科院分区：
文献类型：
--
作者：
Nishikawa J;Nakazawa T;Iizasa H;Jinushi M;Sakaida I;Yoshiyama H.
在本研究中，我们检测了缺氧对人恶性胸膜间皮瘤（MPM）细胞系恶性的影响，发现：(1)缺氧增强了人恶性胸膜间皮瘤（MPM）细胞的运动性和侵袭性；(2)这种现象是通过激活HIF-1通路，唾液化MUC1表达增加所致；(3)位于MUC1启动子区的两个hif结合位点对缺氧条件下MUC1的转激活很重要。这些发现有助于更好地理解MPM细胞侵袭行为的分子机制，并在MPM患者的临床治疗中靶向它们。
In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.