Time course of the induction of homeostatic plasticity generated by repeated transcranial direct current stimulation of the human motor cortex
Time course of the induction of homeostatic plasticity generated by repeated transcranial direct current stimulation of the human motor cortex
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DOI：
10.1152/jn.00608.2009
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发表时间：
2011-03-01
影响因子：
2.5
通讯作者：
Rothwell, J. C.
中科院分区：
文献类型：
--
作者：
Fricke, K.;Seeber, A. A.;Rothwell, J. C.
李建军，李建军，李建军，李建军，李建军。反复经颅直流电刺激人体运动皮层诱导稳态可塑性的时间过程。[J]中国生物医学工程学报，2011,31(2):444 - 444。首次发表于2010年12月22日；doi: 10.1152 / jn.00608.2009。-已经提出了几种机制来控制神经元回路的可塑性，并保证神经网络的动态稳定性。内稳态可塑性表明，突触连接促进/抑制的难易程度取决于先前网络活动的数量。我们描述了这种类似自稳态的相互作用如何取决于两个条件反射协议之间的时间间隔和预处理协议的持续时间。我们使用经颅直流电刺激（tDCS）在健康人的运动皮层中产生短期持续的可塑性。在主要实验中，我们比较了单次5分钟的阳极或阴极tDCS的后效，以及在5分钟tDCS之前30分钟、3分钟或0分钟进行相同的5分钟调理的效果。5分钟淋巴结tDCS兴奋性增加约5分钟。相同时间的阴极tDCS可降低兴奋性。将tDCS持续时间延长至10分钟可延长效果持续时间。如果使用两次5分钟的tDCS，其间间隔30分钟，则第二次tDCS的效果与单独刺激5分钟的效果相同。如果休息时间只有3分钟，那么第二阶段的效果与单独给予5分钟的tDCS相反。对照实验表明，这些可塑性方向的转变在第一次tDCS后的10分钟内发生，并取决于第一次tDCS的持续时间，而不取决于皮质内抑制和促进。结果与时间依赖的“类稳态”规则相一致，该规则支配着人类运动皮层对可塑性探测协议的反应。
Fricke K, Seeber AA, Thirugnanasambandam N, Paulus W, Nitsche MA, Rothwell JC. Time course of the induction of homeostatic plasticity generated by repeated transcranial direct current stimulation of the human motor cortex. J Neurophysiol 105: 1141-1149, 2011. First published December 22, 2010; doi: 10.1152/jn.00608.2009.-Several mechanisms have been proposed that control the amount of plasticity in neuronal circuits and guarantee dynamic stability of neuronal networks. Homeostatic plasticity suggests that the ease with which a synaptic connection is facilitated/suppressed depends on the previous amount of network activity. We describe how such homeostatic-like interactions depend on the time interval between two conditioning protocols and on the duration of the preconditioning protocol. We used transcranial direct current stimulation (tDCS) to produce short-lasting plasticity in the motor cortex of healthy humans. In the main experiment, we compared the aftereffect of a single 5-min session of anodal or cathodal tDCS with the effect of a 5-min tDCS session preceded by an identical 5-min conditioning session administered 30, 3, or 0 min beforehand. Five-minute anodal tDCS increases excitability for about 5 min. The same duration of cathodal tDCS reduces excitability. Increasing the duration of tDCS to 10 min prolongs the duration of the effects. If two 5-min periods of tDCS are applied with a 30-min break between them, the effect of the second period of tDCS is identical to that of 5-min stimulation alone. If the break is only 3 min, then the second session has the opposite effect to 5-min tDCS given alone. Control experiments show that these shifts in the direction of plasticity evolve during the 10 min after the first tDCS session and depend on the duration of the first tDCS but not on intracortical inhibition and facilitation. The results are compatible with a time-dependent "homeostatic-like" rule governing the response of the human motor cortex to plasticity probing protocols.