A dissociation of encoding and retrieval processes in the human hippocampus
A dissociation of encoding and retrieval processes in the human hippocampus
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DOI：
10.1523/jneurosci.3420-04.2005
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发表时间：
2005-03-30
影响因子：
5.3
通讯作者：
Knowlton, BJ
中科院分区：
文献类型：
--
作者：
Eldridge, LL;Engel, SA;Knowlton, BJ
海马结构执行两个相关但不同的记忆功能：编码新信息和检索事件。然而，很少有证据能解释这两个过程是如何在同一解剖结构中实现的。在这里，我们使用高分辨率的功能磁共振成像显示，海马不同的亚区是差异参与编码和检索。我们发现，早期在海马电路（齿状回和CA领域2和3）的区域选择性地活跃在情节记忆的形成，而一个区域后来在电路（下托）是活跃的学习情节的回忆。海马回路的不同组成部分可能对这两种基本记忆功能有不同程度的贡献。
The hippocampal formation performs two related but distinct memory functions: encoding of novel information and retrieval of episodes. Little evidence, however, resolves how these two processes are implemented within the same anatomical structure. Here we use high-resolution functional magnetic resonance imaging to show that distinct subregions of the hippocampus are differentially involved in encoding and retrieval. We found that regions early in the hippocampal circuit (dentate gyrus and CA fields 2 and 3) were selectively active during episodic memory formation, whereas a region later in the circuit (the subiculum) was active during the recollection of the learning episode. Different components of the hippocampal circuit likely contribute to different degrees to the two basic memory functions.