The Role of Leukocytes in Diabetic Cardiomyopathy.

The Role of Leukocytes in Diabetic Cardiomyopathy.
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白细胞在糖尿病心肌病中的作用。

DOI:
10.3389/fphys.2018.01547
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发表时间:
2018
影响因子:
4
通讯作者:
Tilley DG
Tilley DG
中科院分区:
医学2区
文献类型:
--
作者:
Bajpai A;Tilley DG

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糖尿病是心血管疾病如心肌梗死和心力衰竭的主要危险因素。最近,白细胞,特别是中性粒细胞,巨噬细胞和淋巴细胞,已成为研究的目标,因为它们在许多慢性炎症性疾病,如糖尿病和心力衰竭中的潜在作用。虽然白细胞对糖尿病和心力衰竭的进展有重要作用,但对它们参与糖尿病心力衰竭发病机制的了解要少得多。本文综述了白细胞在糖尿病和心力衰竭之间复杂的相互作用中的作用,这对发现糖尿病心肌病的新靶向治疗至关重要。
Diabetes is predominant risk factor for cardiovascular diseases such as myocardial infarction and heart failure. Recently, leukocytes, particularly neutrophils, macrophages, and lymphocytes, have become targets of investigation for their potential role in a number of chronic inflammatory diseases such as diabetes and heart failure. While leukocytes contribute significantly to the progression of diabetes and heart failure individually, understanding their participation in the pathogenesis of diabetic heart failure is much less understood. The present review summarizes the role of leukocytes in the complex interplay between diabetes and heart failure, which is critical to the discovery of new targeted therapies for diabetic cardiomyopathy.
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