The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis.
The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis.
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DOI：
10.2217/imt.12.41
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发表时间：
2012-05
期刊：
影响因子：
2.8
通讯作者：
Cohen JA
中科院分区：
文献类型：
--
作者：
Auletta JJ;Bartholomew AM;Maziarz RT;Deans RJ;Miller RH;Lazarus HM;Cohen JA
多发性硬化症(MS)是一种中枢神经系统炎症性神经退行性疾病，目前仅有部分有效的治疗方法。定义潜在免疫病理生理学的紧张研究正在促进对MS的理解以及揭示疾病干预的潜在靶点。间充质基质细胞(MSC)治疗有可能调节导致MS相关的脱髓鞘和轴突损伤的异常免疫反应，以及修复和恢复受损的CNS组织和细胞。本文回顾了MS的病理生理学基础，并根据参与MS和MSC基础和翻译科学研究的作者的经验，提供了对MSC治疗领域的前沿观点。
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the CNS for which only partially effective therapies exist. Intense research defining the underlying immune pathophysiology is advancing both the understanding of MS as well as revealing potential targets for disease intervention. Mesenchymal stromal cell (MSC) therapy has the potential to modulate aberrant immune responses causing demyelination and axonal injury associated with MS, as well as to repair and restore damaged CNS tissue and cells. This article reviews the pathophysiology underlying MS, as well as providing a cutting-edge perspective into the field of MSC therapy based upon the experience of authors intrinsically involved in MS and MSC basic and translational science research.
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3.2
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