H pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control
H pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control
复制标题
DOI：
10.1136/jcp.51.5.410
复制
发表时间：
1998-05-01
影响因子：
3.4
通讯作者：
Kelleher, D
中科院分区：
文献类型：
--
作者：
Terrés, AM;Pajares, JM;Kelleher, D
细胞外基质蛋白和参与上皮黏附的蛋白是维持组织结构所必需的。幽门螺杆菌是消化性溃疡疾病的主要病原体，已被证明可使患胃癌的风险增加九倍。本研究观察了幽门螺杆菌对细胞外基质蛋白(IV型胶原、纤维连接蛋白和层粘连蛋白)以及细胞-基底和细胞-细胞黏附必需蛋白(α-6-整合素和E-钙粘附素)表达的影响。对感染和非感染患者的胃窦活检切片进行免疫组织化学染色，光镜下观察特异性染色的分布和强度。结果表明，感染与实体组织维持和分化所必需的E-钙粘蛋白表达下调显著相关，但不会引起α6-整合素或细胞外基质蛋白表达的改变。
Extracellular matrix proteins and proteins involved in epithelial adhesion are essential for maintenance of tissue structure. Helicobacter pylori is the major aetiological agent in peptic ulcer disease and has been shown to increase gastric cancer risk up to ninefold. In this study, changes induced by H pylori on the expression of extracellular matrix proteins (collagen IV, fibronectin, and laminin) as well, as two essential proteins for cell-basement and cell-cell adhesion (alpha 6-integrin and E-cadherin) were assessed. Immunohistochemistry was performed in antral biopsy sections obtained from infected and non-infected patients, and light microscopy was used to determine the distribution and intensity of specific staining. The results showed that the infection was significantly associated with downregulation of E-cadherin, an essential protein for maintenance of solid tissues and differentiation, but did not induce changes in the expression of alpha 6-integrin or the extracellular matrix proteins.