Immunotoxicological effects of agent orange exposure to the Vietnam war Korean veterans
Immunotoxicological effects of agent orange exposure to the Vietnam war Korean veterans
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DOI：
10.2486/indhealth.41.158
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发表时间：
2003-07-01
影响因子：
2
通讯作者：
Heo, Y
中科院分区：
文献类型：
--
作者：
Kim, HA;Kim, EM;Heo, Y
2,3,7,8-四氯二苯并-对二恶英（TCDD）的免疫调节作用在动物实验中被证明是胸腺萎缩，下调细胞毒性T或B淋巴细胞的分化或活化，而对人体的免疫毒性尚未得到很好的研究。本研究旨在评估越战朝鲜退伍军人暴露于被TCDD污染的橙剂后的整体免疫谱。与未患橙剂相关慢性疾病的退伍军人和年龄匹配的健康对照相比，患橙剂相关慢性疾病的退伍军人（退伍军人-患者组）的红细胞、血红蛋白和红细胞压积减少，但白细胞数量无差异。由于IgG1水平的显著降低，退伍军人的血浆IgG水平比对照组低。在退伍军人的血浆中观察到IgE水平升高。用多克隆T细胞激活剂激活外周血单个核细胞也可引起T细胞介导免疫的改变。IFNgamma是一种介导宿主抗感染或肿瘤发生的主要细胞因子，其产生在退伍军人患者组中降低。然而，与过敏诱导相关的代表性细胞因子IL-4和IL-10的产生在患者组中增强。总的来说，这项研究表明，在越南服役和/或接触橙剂会扰乱免疫稳态，导致B细胞和T细胞活性失调。
Immunomodulatory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) demonstrated using animals are thymic atrophy, downregulation of cytotoxic T or B lymphocyte differentiation or activation, whereas human immunotoxocities have not been investigated well. This study was undertaken to evaluate overall immunologic spectrum of the Vietnam War Korean veterans exposed to Agent Orange contaminated with TCDD. Quantity of red blood cells, hemoglobin and hematocrit in the veterans suffered from chronic diseases associated with Agent Orange exposure (Veterans-patient group) were decreased in comparison with those of the veterans without the diseases and the age-matched healthy controls, but no differences in leukocyte populations. Plasma IgG levels were lowered in the veterans than the controls, owing to significant decrease in the IgG1 levels. Increase in the IgE levels was observed in the plasma from the veterans. Alteration of T cell-mediated immunity was also resulted from activation of peripheral blood mononuclear cells with polyclonal T cell activators. Production of IFNgamma, a major cytokine mediating host resistance against infection or tumoregenesis, was lowered in the veterans-patient group. However, production of IL-4 and IL-10, representative cytokines involved with hypersensitivity induction, was enhanced in the patient group. Overall, this study suggests that military service in Vietnam and/or Agent Orange exposure disturbs immune-homeostasis resulting in dysregulation of B and T cell activities.