MTI of white matter hyperintensities
MTI of white matter hyperintensities
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DOI：
10.1093/brain/awh567
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发表时间：
2005-12-01
期刊：
影响因子：
14.5
通讯作者：
Schmidt, R
中科院分区：
文献类型：
--
作者：
Fazekas, F;Ropele, S;Schmidt, R
传统 MRI 无法充分确定与老年人偶发白质高信号 (WMH) 相关的组织变化的严重程度。因此，我们对奥地利中风预防研究的 198 名神经学无症状参与者（平均年龄 70 岁，年龄范围 52-87 岁）在 1.5 T 扫描仪上获得的磁化传递比 (MTR) 图进行了区域分析，分析了 WMH 和正常脑组织的预定义区域。流体衰减反转恢复 MRI 用于对病变严重程度进行分级并测量病变体积。 WMH 的 MTR 始终显着低于正常白质 (NAWM)，总体相对降低约 10%，并且随着 WMH 严重程度 (P = 0.02) 和 WMH 体积 (r = -0.24，P = 0.0016) 评分的增加而显着下降。 NAWM MTR 在 WMH 很少和广泛的受试者之间没有差异，并且 WMH 体积仅与额叶的 NAWM MTR 相关。关于可能对大脑功能的影响，额叶 NAWM 的 MTR 与精细运动灵活性显着相关（P = 0.04），但与认知表现无关。在 NAWM 和皮质中均观察到 MTR 随着衰老而显着下降，但在 WMH 中则没有。我们得出结论，MTR 测量可以用来量化 WMH 相关的组织损伤。它主要是局灶性的，相对温和，随着病变大小的增加而增加，并且可能对额叶白质产生远程影响。
The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian Stroke Prevention Study (mean age 70, age range 52-87 years) in regard to WMH and predefined areas of normal appearing brain tissue. Fluid attenuated inversion recovery MRI was used to grade lesion severity and for lesion volume measurements. The MTR of WMH was always significantly lower than that of normal appearing white matter (NAWM) with an overall relative reduction of similar to 10% and decreased significantly with increasing scores of WMH severity (P = 0.02) and WMH volume (r = -0.24, P = 0.0016). NAWM MTR was not different between subjects with very few and extensive WMH and the WMH volume was associated with NAWM MTR of the frontal lobes only. Concerning a possible impact on cerebral functioning the MTR of the frontal NAWM was significantly associated with fine motor dexterity (P = 0.04) but not with cognitive performance. A significant decline of the MTR with aging was seen in both NAWM and cortex but not in WMH. We conclude that MTR measurements can serve to quantify WMH associated tissue damage. It is predominantly focal, relatively mild, increases with lesion size and may have remote effects on the frontal white matter.