DIFFERENTIAL EFFECTS OF ICV MICROINFUSION OF AGMATINE ON SPATIAL WORKING AND REFERENCE MEMORY IN THE RAT
DIFFERENTIAL EFFECTS OF ICV MICROINFUSION OF AGMATINE ON SPATIAL WORKING AND REFERENCE MEMORY IN THE RAT
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DOI：
10.1016/j.neuroscience.2009.01.039
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发表时间：
2009-03-31
期刊：
影响因子：
3.3
通讯作者：
Bergin, D. H.
中科院分区：
文献类型：
--
作者：
Liu, P.;Bergin, D. H.
最近的研究表明，胍丁胺是精氨酸脱羧酶代谢精氨酸的产物，存在于哺乳动物脑内，是一种新的神经递质。外源性胍丁胺可调节行为功能，包括学习记忆。本研究探讨了悔罪i. c. v.微量注射胍丁胺（每日一次）对水迷宫任务的参考和工作记忆版本，以及高架十字迷宫和开放领域的影响。与盐水对照组相比，高剂量（100 μ g）而非低剂量（10 μ g）胍丁胺组大鼠在第1天（接受3次输注），但在第12天（接受14次输注），在开放视野中的探索和自主活动减少。这三个组在开放视野之前测试的高架十字迷宫中的两天表现相似。在水迷宫任务的参考记忆版本中，在线索导航（第2天）、位置导航（第3-7天）和探测测试（第7天）中，以两种剂量的胍丁胺处理的大鼠以及盐水对照进行。在水迷宫任务的工作记忆版本中（第8-11天），与盐水组相比，两个胍丁胺组产生的路径长度明显缩短，到达平台的时间明显缩短，延迟时间为180秒，但不是30秒。这些结果表明，重复胍丁胺治疗产生短暂的损害，在开放领域的探索和自发活动，在剂量依赖性的方式。胍丁胺显著促进空间工作记忆的延迟时间较长，但不促进参考记忆，这表明胍丁胺对两种类型的空间学习和记忆的影响不同。今后需要探讨其内在机制。(C)2009年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Recent evidence suggests that agmatine, the metabolite of arginine by arginine decarboxylase, exists in the mammalian brain and is a novel neurotransmitter. Exogenous agmatine can modulate behaviour function, including learning and memory. The present study investigated the effects of repented i.c.v. microinfusion of agmatine (once daily) on the reference and working memory versions of the water maze task, as well as the elevated plus maze and open field. Rats with high (100 mu g), but not low (10 mu g), dose of agmatine displayed reduced exploratory and locomotor activity in the open field relative to the saline controls on day 1 (received three infusions), but not day 12 (received 14 infusions). The three groups performed similarly on both days in the elevated plus maze tested prior to the open field. In the reference memory version of the water maze task, rats with agmatine treatment at both doses performed as well as the saline controls in the cued navigation (day 2), place navigation (days 3-7) and probe test (day 7). In the working memory version of the water maze task (days 8-11), the two agmatine groups generated markedly shorter path length and took significantly less time to reach the platform at the 180 s, but not 30 s, delay as compared to the saline group. These results demonstrate that repeated agmatine treatment produces transient impairments in exploratory and locomotor activity in the open field in a dose-dependent manner. Agmatine significantly facilitates spatial working memory at a longer delay, but not reference memory, suggesting its differential influence on the two types of spatial learning and memory. The underlying mechanisms need to be explored in the future. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.