Perinatal risk factors and infantile autism
Perinatal risk factors and infantile autism
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DOI：
10.1111/j.1600-0447.2006.00805.x
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发表时间：
2006-10-01
影响因子：
6.7
通讯作者：
Vaeth, M.
中科院分区：
文献类型：
--
作者：
Maimburg, R. D.;Vaeth, M.
目的：怀孕和分娩期间的不理想条件已被认为是婴儿自闭症的一个原因。我们研究了产科因素与婴儿自闭症之间的关系。方法：一项以人群为基础的儿童自闭症匹配病例对照研究。使用条件逻辑回归计算优势比（OR）和95%置信区间（CI）。结果：5 ~ 35岁的外籍母亲和怀孕期间服用药物的母亲患婴儿自闭症的风险增加。低出生体重和先天畸形的儿童患自闭症的风险更高。分娩干预、病理性心脏造影、绿色羊水和分娩时的酸中毒与婴儿自闭症的风险增加无关。结论：我们的研究结果表明，不理想的出生条件不是婴儿自闭症的独立危险因素。自闭症患者中普遍存在的低出生体重和出生缺陷似乎解释了不理想的出生结果。
Objective: Suboptimal conditions during pregnancy and birth have been suggested as a cause of infantile autism. We have studied the association between obstetric factors and infantile autism.Method: A population-based, matched case-control study of infantile autism. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI).Results: The risk of infantile autism was increased for mothers aged > 35 years, with foreign citizenship, and mothers who used medicine during pregnancy. A higher risk of infantile autism was seen among children with low birth weight and with congenital malformations. Birth interventions, pathological cardiotocography, green amnion fluid and acidosis during delivery were not associated with increased risk for infantile autism.Conclusion: Our findings suggest that suboptimal birth conditions are not an independent risk factor for infantile autism. A high prevalence of low birth weight and birth defects among autism cases seems to explain the suboptimal birth outcome.