Similar effects of treatment with desipramine and electroconvulsive shock on 5-hydroxytryptamine1A receptors in rat brain.
Similar effects of treatment with desipramine and electroconvulsive shock on 5-hydroxytryptamine1A receptors in rat brain.
复制标题
地昔帕明和电休克治疗对大鼠脑中 5-羟色胺 1A 受体的类似作用。
DOI：
10.1016/0014-2999(91)90297-4
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发表时间：
1991
影响因子：
5
通讯作者：
Pandey,GN
中科院分区：
文献类型：
--
作者：
Pandey,SC;Isaac,L;Davis,JM;Pandey,GN
本实验观察了地昔帕明（Desipramine，DSI）和电休克（Electroconvulsive Shock，ECS）对大鼠皮层和海马5-羟色胺1A（5-HT 1A）受体的影响。我们观察到，长期治疗与ESTA和ECS显着减少5-HT 1A受体，确定[3 H]8-羟基-2-（二正丙基氨基）四氢萘（[3 H]8-OH-DPAT）结合，在皮层，但不是在海马。急性给药后皮质5-HT_（1A）受体无明显改变。无论是慢性还是急性治疗都不影响皮质或海马中[3 H] 8-OH-DPAT结合的KD。因此，这些结果表明，与对5-HT 2受体的作用相反，三环类药物以及ECS对5-HT 1A受体产生类似的作用，表明该位点可能代表抗抑郁治疗的共同作用位点。
The effect of chronic and acute treatment with desipramine (DMI) and electroconvulsive shock (ECS) on 5-hydroxytryptamine1A(5-HT1A) receptors was determined in the cortex and the hippocampus brain regions of rats. We observed that chronic treatment with both DMI and ECS significantly decreased 5-HT1Areceptors, as determined by [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) binding, in the cortex but not in the hippocampus. Acute treatment with DMI or ECS did not significantly alter the 5-HT1Areceptors in the cortex. Neither chronic nor acute treatment influenced KDof [3H)8-OH-DPAT binding in the cortex or hippocampus. These results thus suggest that in contrast to the effects on 5-HT2receptors, tricyclics as well as ECS produce similar effects on 5-HT1Areceptors, suggesting that this site may represent a common site of action for antidepressant treatment.