Sleep changes in smokers before, during and 3 months after nicotine withdrawal
Sleep changes in smokers before, during and 3 months after nicotine withdrawal
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DOI：
10.1111/adb.12151
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发表时间：
2015-07-01
影响因子：
3.4
通讯作者：
Riemann, Dieter
中科院分区：
文献类型：
--
作者：
Jaehne, Andreas;Unbehaun, Thomas;Riemann, Dieter
尼古丁可能通过影响睡眠调节神经递质来影响睡眠。睡眠障碍会增加抑郁和物质依赖的风险。为了检测睡眠障碍对戒烟效果的影响，我们通过多导睡眠图（PSG）研究了吸烟受试者在吸烟期间、戒断期间和戒烟一段时间后的睡眠情况。对 33 名吸烟者（23 名男性，10 名女性，中位年龄 29 岁，Fagerstrom 尼古丁依赖性测试得分 6.3）在吸烟期间、吸烟后 24-36 小时和戒烟后 3 个月进行了检查。所有受试者都经历了适应之夜，然后是 PSG 之夜。与吸烟状态相比，我们发现尼古丁戒断期间的唤醒指数和觉醒时间增加。后来复吸的吸烟者 (11) 比戒烟者 (22) 表现出更高程度的尼古丁依赖和更多的戒断症状，其特点是快速眼动 (REM) 睡眠较少、REM 潜伏期较长，以及戒断期间主观睡眠评分中更严重的睡眠障碍。戒断阶段的睡眠障碍可能反映了更严重的尼古丁依赖，并可能导致吸烟行为的早期复发。
Nicotine may affect sleep by influencing sleep-regulating neurotransmitters. Sleep disorders can increase the risk for depression and substance dependency. To detect the influence of sleep disturbances on the effect of smoking cessation, we investigated polysomnographically (PSG) the sleep of smoking subjects during a period of smoking, during withdrawal and after a period of abstinence from nicotine. Thirty-three smokers (23 male, 10 female, median age 29 years, Fagerstrom Test for Nicotine Dependence score 6.3) were examined during smoking, 24-36 hours after smoking and 3 months after cessation. All subjects had an adaptation night followed by the PSG night. Compared with the smoking state, we found increased arousal index and wake time during nicotine withdrawal. Smokers who later relapsed (11) presented a higher degree of nicotine dependence and more withdrawal symptoms than those who abstained (22) and were characterized by less rapid eye movement (REM) sleep, a longer REM latency as well as by more intense sleep impairments in the subjective sleep rating during the withdrawal. Impairments of sleep during the withdrawal phase may reflect more severe nicotine dependence and may contribute to earlier relapse into smoking behaviours.