Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms
Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms
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DOI：
10.1097/01.ccm.0000150025.79100.7d
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发表时间：
2005-01-01
影响因子：
8.8
通讯作者：
Tokuhisa, T
中科院分区：
文献类型：
--
作者：
Watanabe, E;Hirasawa, H;Tokuhisa, T
目的：为了确定白细胞介素（IL）-6-、IL-1-和肿瘤坏死因子-α（TNF）相关基因多态性在具有极高IL-6血液水平的危重患者中的等位基因频率，并检查其临床病程的遗传效应。共招募了150名重症监护室入院时的连续危重患者，无论诊断，和150名健康志愿者。测量和主要结果：IL-6的血液水平，每天用化学发光免疫法测定。IL-6峰值水平与同时测量的TNF显著相关（r = 0.659，p
Objective: To determine the allelic frequencies of interleukin (IL)-6-,IL-l-, and tumor necrosis factor-alpha (TNF)-related gene polymorphisms in critically ill patients with extremely high IL-6 blood level and to examine the genetic effects on their clinical courses.Design: Population-based association study.Setting: A general intensive care unit in a university teaching hospital.Patients: A total of 150 consecutive critically ill patients recruited at admission to the intensive care unit, regardless of diagnosis, and 150 healthy volunteers.Measurements and Main Results: IL-6 blood levels were measured daily with chemiluminescence immunoassay. The IL-6 peak levels were significantly correlated with simultaneously measured TNF (r =.659, p