The Effect of Tyramine, Noradrenaline, and Angiotensin on the Blood Pressure in Hypertensive Patients with Aldosteronism and Low Plasma Renin *
The Effect of Tyramine, Noradrenaline, and Angiotensin on the Blood Pressure in Hypertensive Patients with Aldosteronism and Low Plasma Renin *
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酪胺、去甲肾上腺素和血管紧张素对醛固酮增多症和低血浆肾素的高血压患者血压的影响*
DOI：
10.1111/j.1365-2362.1970.tb00617.x
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发表时间：
1970
影响因子：
5.5
通讯作者：
H. P.Wolff
中科院分区：
文献类型：
--
作者：
A. Distler;C. Barth;H. Liebau;P. Vécsei;H. P.Wolff
本文测定了9例高血压、醛固酮增多症和低血浆肾素水平患者（4例单发肾上腺腺瘤，3例结节性肾上腺增生，2例肾上腺状态不明）对酪胺、去甲肾上腺素和血管紧张素的升压反应。7例患者分别在单侧或次全肾上腺切除术后重复测试。作为比较，5例嗜铬细胞瘤患者，10例良性原发性高血压患者，和12名血压正常的对照组进行了研究。- 在伴有醛固酮增多症和低血浆肾素的高血压患者中，对酪胺的反应性显著降低。相反，对去甲肾上腺素的升压反应在正常范围内，对血管紧张素的敏感性增加。肾上腺手术后，对酪胺的敏感性增加，但在所有情况下，去甲肾上腺素的敏感性没有显着变化，血管紧张素的反应性下降，但在所有情况下，一个。- 本文讨论了酪胺对伴有醛固酮增多症的高血压患者的降压作用降低是由于肾上腺素能功能紊乱，这可能对这些高血压患者的肾素产生减少具有重要意义。
Abstract The reactivity to the pressor action of tyramine, noradrenaline, and angiotensin was determined in 9 patients with hypertension, aldosteronism and low plasma renin concentration (4 patients with solitary adrenal adenomas, 3 patients with nodular adrenal hyperplasia, 2 patients with unknown adrenal status). In 7 patients tests were repeated following unilateral or subtotal adrenalectomy respectively. For comparison, 5 patients with phaeochromocytoma, 10 patients with benign essential hypertension, and 12 normotensive control subjects were studied. — In the hypertensive patients with aldosteronism and low plasma renin, responsiveness to tyramine was significantly reduced. In contrast, pressor response to noradrenaline was in the normal range, and sensitivity to angiotensin was increased. Following adrenal surgery, sensitivity to tyramine increased in all cases but one, sensitivity to noradrenaline did not change significantly, and responsiveness to angiotensin decreased in all cases but one. — It is discussed that the reduced pressor effect of tyramine in the hypertensive patients with aldosteronism is due to a disturbance of adrenergic function which may be of importance for the diminished production of renin in these forms of hypertension.