The processing and presentation of endogenous and exogenous antigen by Schwann cells in vitro
The processing and presentation of endogenous and exogenous antigen by Schwann cells in vitro
复制标题
DOI：
10.1007/s000180200018
复制
发表时间：
2002-12-01
影响因子：
8
通讯作者：
Lilje, O
中科院分区：
文献类型：
--
作者：
Lilje, O
主要组织相容性复合物II类在体外和体内的雪旺氏细胞的表达表明，在炎症性脱髓鞘性神经病变的抗原的神经原性T细胞的雪旺氏细胞的潜在的兼性作用。本研究采用T细胞增殖试验，证明雪旺细胞对内源性和外源性抗原的加工和呈递影响T细胞增殖，并对雪旺细胞对抗原的加工和呈递与T细胞增殖的关系进行了统计分析。包括培养物的处理（未处理的、辐射的或固定的）、外源抗原的浓度（0或40 μ g/ml）、干扰素-γ的存在和外源抗原添加的时机在内的因素的不同组合影响P-2特异性、非哺乳动物蛋白卵清蛋白特异性T细胞系和初始T细胞的增殖。
The expression of major histocomatibility complex class II in vitro and in vivo by Schwann cells indicates a potential facultative role of Schwann cells in the presentation of antigen to neuritogenic T cells during inflammatory demyelinating neuropathies. Using a T cell proliferation assay, this study demonstrated that processing and presentation of endogenous and exogenous antigen by Schwann cells influences T cell proliferation, Statistical analysis of proliferation and its relation to processing and presentation of antigen by Schwann cells had not been previously addressed. Different combinations of factors including treatment of cultures (untreated, irradiated or fixed), concentration of exogenous antigen (0 or 40 mug/ml), the presence of interferon-gamma and the timing of exogenous antigen addition influence the proliferation P-2-specific, non-mammalian protein ovalbumin-specific T cell lines and naive T cells.