Clinical application of readout-segmented- echo-planar imaging for diffusion-weighted imaging in pediatric brain.
Clinical application of readout-segmented- echo-planar imaging for diffusion-weighted imaging in pediatric brain.
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在小儿大脑中进行扩散加权成像的读取 - 回声 - 平面成像的临床应用。
DOI：
10.3174/ajnr.a2481
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Bammer R
中科院分区：
文献类型：
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作者：
Holdsworth SJ;Yeom K;Skare S;Gentles AJ;Barnes PD;Bammer R
RS-EPI已被建议作为EPI的替代方法，用于高分辨率DWI，减少失真。为了确定RS-EPI是否是常规临床使用的有用方法，我们在儿科医院实施了GRAPPA加速RS-EPI DWI，并将图像与常规用于临床研究的标准加速（ASSET）EPI DWI一起分级。使用3T系统对35例儿科患者采集了GRAPPA加速RS-EPI DWI和ASSET EPI DWI。使用7分制Likert量表对图像进行分级，如下所示：1，非诊断性; 2，差; 3，可接受; 4，标准; 5，高于平均水平; 6，良好; 7，突出。以下分别是EPI和RS-EPI的平均评分：分辨率，3.5/5.2;失真水平，2.9/6.0; SNR，3.4/4.1;病变明显性，3.3/5.9;和诊断置信度，3.2/6.0。总体而言，RS-EPI显著提高了诊断信心，并更可靠地确定了几个病变的范围和结构。虽然ASSET EPI扫描在每个扫描时间内具有更好的SNR，但RS-EPI扫描的更高空间分辨率以及减少的模糊和失真有助于更好地显示皮质-皮质下水平、脑干、颞叶和下额叶、颅底、鼻窦腔、颅神经和眼眶的重要解剖细节。这项工作显示了分辨率和减少失真在临床中的重要性，这可以通过并行成像和替代k空间轨迹（如RS-EPI）的组合来实现。
RS-EPI has been suggested as an alternative approach to EPI for high-resolution DWI with reduced distortions. To determine whether RS-EPI is a useful approach for routine clinical use, we implemented GRAPPA-accelerated RS-EPI DWI at our pediatric hospital and graded the images alongside standard accelerated (ASSET) EPI DWI used routinely for clinical studies. GRAPPA-accelerated RS-EPI DWIs and ASSET EPI DWIs were acquired on 35 pediatric patients using a 3T system in 35 pediatric patients. The images were graded alongside each other by using a 7-point Likert scale as follows: 1, nondiagnostic; 2, poor; 3, acceptable; 4, standard; 5, above average; 6, good; and 7, outstanding. The following were the average scores for EPI and RS-EPI, respectively: resolution, 3.5/5.2; distortion level, 2.9/6.0; SNR, 3.4/4.1; lesion conspicuity, 3.3/5.9; and diagnostic confidence, 3.2/6.0. Overall, the RS-EPI had significantly improved diagnostic confidence and more reliably defined the extent and structure of several lesions. Although ASSET EPI scans had better SNR per scanning time, the higher spatial resolution as well as reduced blurring and distortions on RS-EPI scans helped to better reveal important anatomic details at the cortical-subcortical levels, brain stem, temporal and inferior frontal lobes, skull base, sinonasal cavity, cranial nerves, and orbits. This work shows the importance of both resolution and decreased distortions in the clinics, which can be accomplished by a combination of parallel imaging and alternative k-space trajectories such as RS-EPI.