A model for red blood cell motion in glycocalyx-lined capillaries
A model for red blood cell motion in glycocalyx-lined capillaries
复制标题
DOI：
10.1152/ajpheart.1998.274.3.h1016
复制
发表时间：
1998-03-01
影响因子：
4.8
通讯作者：
Pries, AR
中科院分区：
文献类型：
--
作者：
Secomb, TW;Hsu, R;Pries, AR
毛细血管的内表面衬有一层结合或吸附在内皮上的大分子（糖萼）。在这里，一个理论模型是用来分析的影响，糖萼对红细胞压积和阻力毛细血管中的血流。糖萼被表示为抵抗红细胞渗透的多孔层。假设红细胞形状为轴对称，并考虑了细胞膜剪切弹性的影响。润滑理论用于计算细胞周围和糖萼内的血浆流动。预测的糖萼管红细胞压积（Fahraeus效应）和流动阻力的影响作为层的宽度和水力电阻率的函数。一个宽度为1 μ m、电阻率为10（8）dyn.s/cm（4）的层，在6 μ m毛细管中，在排出血细胞比容为45%、流速为1 mm/s时，其相对表观粘度近似为10。这与相对于具有相同直径的玻璃管，体内微血管中流动阻力增加的实验观察结果一致。
The interior surfaces of capillaries are lined with a layer (glycocalyx) of macromolecules bound or adsorbed to the endothelium. Here, a theoretical model is used to analyze the effects of the glycocalyx on hematocrit and resistance to blood flow in capillaries. The glycocalyx is represented as a porous layer that resists penetration by red blood cells. Axisymmetric red blood cell shapes are assumed, and effects of cell membrane shear elasticity are included. Lubrication theory is used to compute the flow of plasma around the cell and within the glycocalyx. The effects of the glycocalyx on tube hematocrit (Fahraeus effect) and on flow resistance are predicted as functions of the width and hydraulic resistivity of the layer. A layer of width 1 mu m and resistivity 10(8) dyn.s/cm(4) leads to a relative apparent viscosity of similar to 10 in a 6-mu m capillary at discharge hematocrit 45% and flow velocity of similar to 1 mm/s. This is consistent with experimental observations of increased flow resistance in microvessels in vivo, relative to glass tubes with the same diameters.