Finite element modelling of sound transmission in the Weberian apparatus of zebrafish (Danio rerio).
Finite element modelling of sound transmission in the Weberian apparatus of zebrafish (Danio rerio).
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DOI：
10.1098/rsif.2023.0553
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发表时间：
2024-01
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影响因子：
--
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中科院分区：
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--
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斑马鱼是一种重要的脊椎动物模型，它极大地扩展了我们对听觉的理解。然而，一个尚未探索的领域是韦伯装置的生物力学，这对声音传导和感知至关重要。使用微计算机断层扫描（μCT）生物成像，我们创建了斑马鱼韦伯听小骨的三维有限元模型。这些模型的范围从精确尺寸到几何形状受限（听骨链长度为1至10 mm）的缩放等距版本。对所有11个模型的谐波有限元分析显示，斑马鱼的韦伯听骨链的共振频率约为900 Hz，与其最佳听力范围相匹配。有趣的是，共振频率与尺寸呈负相关，而三角骨和舟骨的峰值位移比和共振频率差保持不变。这表明听骨链的传输效率和听骨链两端共振频率的均匀性不依赖于尺寸。我们的结论是韦伯器的共振频率可以解释斑马鱼的最佳听觉频率，其生物力学特性不受等长个体发育。作为第一个无鼓室耳的生物力学模型和为数不多的非人耳模型，这项研究提供了一个方法框架，为进一步研究听觉机制和听觉进化的脊椎动物。
Zebrafish, an essential vertebrate model, has greatly expanded our understanding of hearing. However, one area that remains unexplored is the biomechanics of the Weberian apparatus, crucial for sound conduction and perception. Using micro-computed tomography (μCT) bioimaging, we created three-dimensional finite element models of the zebrafish Weberian ossicles. These models ranged from the exact size to scaled isometric versions with constrained geometry (1 to 10 mm in ossicular chain length). Harmonic finite element analysis of all 11 models revealed that the resonance frequency of the zebrafish's Weberian ossicular chain is approximately 900 Hz, matching their optimal hearing range. Interestingly, resonance frequency negatively correlated with size, while the ratio of peak displacement and difference of resonance frequency between tripus and scaphium remained constant. This suggests the transmission efficiency of the ossicular chain and the homogeneity of resonance frequency at both ends of the chain are not size-dependent. We conclude that the Weberian apparatus's resonance frequency can explain zebrafish's best hearing frequency, and their biomechanical characteristics are not influenced by isometric ontogeny. As the first biomechanical modelling of atympanic ear and among the few non-human ear modelling, this study provides a methodological framework for further investigations into hearing mechanisms and the hearing evolution of vertebrates.
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影响因子：
2.4
作者：
FUNNELL, WRJ;LASZLO, CA
通讯作者：
LASZLO, CA
影响因子：
2.4
作者：
Finneran, JJ;Hastings, MC
通讯作者：
Hastings, MC
DOI：
10.1111/j.1096-3642.2003.00097.x
发表时间：
2004-02-01
影响因子：
2.8
作者：
Grande, T;Young, B
通讯作者：
Young, B
影响因子：
1.5
作者：
Bird, Nathan C.;Hernandez, L. Patricia
通讯作者：
Hernandez, L. Patricia
影响因子：
2.8
作者：
Capshaw，Grace;Brown，Andrew D.;McCullagh，Elizabeth A.
通讯作者：
McCullagh，Elizabeth A.