Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles
Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles
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DOI：
10.1007/bf03401725
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发表时间：
1998-01-01
影响因子：
5.7
通讯作者：
Jones, KW
中科院分区：
文献类型：
--
作者：
Peroutka, SJ;Price, SC;Jones, KW
背景：直接采访无关个体（n = 242）是否存在偏头痛、焦虑症和重度抑郁症。 材料和方法：本研究中描述的数据来自最初为偏头痛遗传分析而开发的临床通用关系数据库。使用先前描述的引物对位于外显子 6 (His313His) 的 DRD2 NcoI C 至 T 多态性进行基因分型。结果：与具有 DRD2 NcoI T 等位基因的个体相比，在具有 DRD2 NcoI CIC 基因型的个体中观察到先兆偏头痛 (MWA)、重度抑郁症、广泛性焦虑症 (GAD)、惊恐发作和恐惧症的发生率显着增加。具体来说，本研究中 69% (91/131) 的 DRD2 NcoI CIC 个体至少符合其中一种神经精神疾病的标准，而 DRD2 NcoI T/T 个体中只有 22% (4/18) (卡方 = 15.29；p < 0.00005)。患有 MWA、焦虑症和/或重度抑郁症的个体（C 等位基因频率 = 0.80）的 DRD2 NcoI C 等位基因频率显着高于没有这些疾病的个体（C 等位基因频率 = 0.67）。 结论：这些数据表明，MWA、焦虑症和重度抑郁症可能是与等位基因变异相关的独特临床综合征的组成部分。 DRD2 基因。这种基于遗传的综合征的临床识别具有重要的诊断和治疗意义。
Background: Unrelated individuals (n = 242) were interviewed directly for the presence of migraine, anxiety disorders, and major depression.Materials and Methods: The data described in this study are derived from a clinical generic relational data base that was developed initially for the genetic analysis of migraine. Genotyping of the DRD2 NcoI C to T polymorphism located in exon 6 (His313His) was performed using previously described primers.Results: A significantly increased incidence of migraine with aura (MWA), major depression, generalized anxiety disorder (GAD), panic attacks, and phobia was observed in individuals with the DRD2 NcoI CIC genotype compared with individuals with an DRD2 NcoI T allele. Specifically, 69% (91/131) of DRD2 NcoI CIC individuals in the present study met criteria for at feast one of these neuropsychiatric disorders versus only 22% (4/18) of the DRD2 NcoI T/T individuals (Chi-square = 15.29; p < 0.00005). The DRD2 NcoI C allele frequency is significantly higher (Chi-square = 17.13; p < 0.00002) in individuals with MWA, anxiety disorders, and/or major depression (C allele frequency = 0.80) than in individuals who have none of these disorders (C allele frequency = 0.67).Conclusions: These data indicate that MWA, anxiety disorders, and major depression can be components of a distinct clinical syndrome associated with allelic variations within the DRD2 gene. Clinical recognition of this genetically based syndrome has significant diagnostic and therapeutic implications.