A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase.
A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase.
复制标题
氢过氧化物介导的前列环素合成酶失活机制。
作者：
SJ Weiss;J. Turk;P. Needleman
在血红素催化的 15-氢过氧花生四烯酸分解过程中，证实了羟基自由基的产生。氢过氧化物介导的前列环素合成酶失活似乎与这种高反应性物质的产生有关。氢过氧化物和羟基自由基之间的关系可能对于疾病状态下前列环素合成的调节很重要。
Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in diseased states.