Bile acid nuclear receptor FXR and digestive system diseases.
Bile acid nuclear receptor FXR and digestive system diseases.
复制标题
DOI：
10.1016/j.apsb.2015.01.004
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Ding L;Yang L;Wang Z;Huang W
胆汁酸不仅是一种消化表面活性剂，而且是重要的细胞信号分子，通过刺激多种信号通路来调节一些重要的生物过程。胆汁酸激活的核受体farnesoid X受体（FXR）在调节胆汁酸、脂质和葡萄糖稳态以及调节肠道炎症反应、屏障功能和预防细菌易位方面起着关键作用。正如预期的那样，FXR参与了广泛的胃肠道疾病的病理生理，包括炎症性肠病、结直肠癌和2型糖尿病。在这篇综述中，我们讨论了FXR在消化系统生理学和相关疾病中的作用。更好地了解FXR在消化系统中的作用将加速FXR配体/调节剂的开发，用于治疗消化系统疾病。胆汁酸激活的核受体farnesoid X受体（FXR）参与多种胃肠道疾病的病理生理，包括炎症性肠病、结直肠癌和2型糖尿病。本文综述了FXR在消化系统生理及相关疾病中的作用。
Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, barrier function and prevention of bacterial translocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), is involved in the pathophysiology of a wide range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, authors discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases.