STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.
STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.
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STK17B 通过 AKT/GSK-3β/Snail 信号传导促进肝细胞癌的癌变和转移。
DOI：
10.1038/s41419-018-0262-1
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发表时间：
2018-02-14
影响因子：
9
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Lan Y;Han J;Wang Y;Wang J;Yang G;Li K;Song R;Zheng T;Liang Y;Pan S;Liu X;Zhu M;Liu Y;Meng F;Mohsin M;Cui Y;Zhang B;Subash S;Liu L
肝细胞癌（HCC）是世界范围内常见的肝内和远处转移的致死性恶性肿瘤。阐明调节HCC进展的潜在分子机制对于探索新的治疗策略至关重要。丝氨酸/苏氨酸激酶17B （STK17B）在HCC组织中上调，但其在HCC进展中的作用尚不清楚。在目前的研究中，我们报道了STK17B在HCC进展中起关键作用。STK17B在HCC细胞系和标本中显著上调，异位STK17B表达的患者具有较差的临床病理特征。体外和体内实验表明，抑制STK17B可显著抑制HCC的肿瘤发生和转移，而STK17B过表达可促进这一过程。此外，我们发现STK17B通过激活AKT/GSK-3β/Snail信号通路促进EMT过程，miR-455-3p被鉴定为STK17B的上游调节因子。高水平的STK17B和低水平的miR-455-3p联合预测HCC患者预后较差，准确率较高。综上所述，我们的研究表明STK17B通过激活AKT/GSK-3β/Snail信号促进HCC进展，诱导EMT过程，并预测HCC预后不良。
Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide with frequent intrahepatic and distant metastasis. Elucidating the underlying molecular mechanism that modulates HCC progression is critical for exploring novel therapeutic strategies. Serine/Threonine Kinase 17B (STK17B) is upregulated in HCC tissues, but its role in HCC progression remains elusive. In the present studies, we reported that STK17B had a critical role in HCC progression. STK17B was significantly upregulated in HCC cell lines and specimens, and patients with ectopic STK17B expression characterized with poor clinicopathological features. In vitro and in vivo assay demonstrated that inhibition of STK17B markedly inhibits HCC tumorigenesis and metastasis, while STK17B overexpression promoted these processes. Furthermore, we found that STK17B promoted EMT process via activating AKT/GSK-3β/Snail signal pathway, and miR-455-3p was identified as the upstream regulator of STK17B. Combination of high level of STK17B and low level of miR-455-3p predicted poor prognosis with higher accuracy for HCC patients. In conclusion, our research demonstrated that STK17B promotes HCC progression, induces EMT process via activating AKT/GSK-3β/Snail signal and predicts poor prognosis in HCC.
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二苯基二氟酮：人类肝细胞癌的有效化疗候选物。
影响因子：
3.7
作者：
Liang Y;Yin D;Hou L;Zheng T;Wang J;Meng X;Lu Z;Song X;Pan S;Jiang H;Liu L
通讯作者：
Liu L
影响因子：
2.7
作者：
Jung, Myoung Eun;Byun, Byung Jin;Choi, Gildon
通讯作者：
Choi, Gildon
DOI：
10.1007/978-1-4419-0711-0_2
发表时间：
2010-01-01
期刊：
CANCER GENOME AND TUMOR MICROENVIRONMENT
影响因子：
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作者：
Bellacosa, A.;Larue, L.
通讯作者：
Larue, L.
钙网蛋白通过调节 Smad 信号和钙信号来调节 TGF-β1 诱导的上皮间质转化
DOI：
10.1016/j.biocel.2017.07.023
发表时间：
2017-09-01
影响因子：
4
作者：
Wu, Yanjiao;Xu, Xiaoli;Tang, Liling
通讯作者：
Tang, Liling
影响因子：
13.5
作者：
Liu, Lulu;Dai, Yongdong;Guan, Xin-Yuan
通讯作者：
Guan, Xin-Yuan