Polyurethane scaffold in lateral meniscus segmental defects: Clinical outcomes at 24 months follow-up
Polyurethane scaffold in lateral meniscus segmental defects: Clinical outcomes at 24 months follow-up
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DOI：
10.1016/j.otsr.2013.10.011
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发表时间：
2014-02-01
影响因子：
2.3
通讯作者：
Verdonk, R.
中科院分区：
文献类型：
--
作者：
Bouyarmane, H.;Beaufils, P.;Verdonk, R.
背景资料：外侧半月板节段性组织缺损与疼痛和骨关节炎风险增加相关，即使已仔细考虑适应症。假设：使用新型可生物降解支架修复缺损将减轻疼痛并恢复膝关节功能。方法：在这项前瞻性多中心研究中，共纳入54例患者（37例男性/17例女性;平均年龄：28岁[16-50]）。所有患者均出现半月板切除术后综合征和节段性外侧半月板丧失，并在关节镜下植入聚氨酯可生物降解支架（Actifit（R），Orteq）进行治疗。结果：术后6个月、12个月、24个月时，VAS评分从术前的5.5分下降到术后6个月的3.6分、12个月的3.4分、24个月的2.9分。IKDC从基线时的47.0改善至6、12和24个月时的60.2、67.0和67.0。所有KOOS子评分改善基线和24 months.Discussion：本研究的临床结果表明，在临床和统计学显着改善疼痛和功能评分（VAS，IKDC，和所有KOOS子量表，除运动），在6个月的后续行动和所有临床结果在2年的后续行动。Actifit（R）支架在治疗外侧半月板缺损方面是安全有效的。(C)2013年Elsevier Masson SAS。All rights reserved.
Background: Segmental tissue loss in the lateral meniscus is associated with pain and increased risk of osteoarthritis even when indications have been carefully considered.Hypothesis: Repairing the defect using a novel biodegradable scaffold will reduce pain and restore the knee function.Methods: In this prospective multicenter study, a total of 54 patients (37 males/17 females; mean age: 28 years [16-50]) were enrolled. All patients presented with postmeniscectomy syndrome and segmental lateral meniscus loss, and were treated with a polyurethane biodegradable scaffold (Actifit (R), Orteq) implanted arthroscopically. Clinical outcomes were assessed at 6, 12 and 24 months using Visual Analogue Scale (VAS), International Knee Documentation Committee Score (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS).Results: VAS decreased from 5.5 at baseline to 3.6 at 6 months, 3.4 at 12 months and 2.9 at 24 months. IKDC improved from 47.0 at baseline to 60.2, 67.0 and 67.0 at 6, 12 and 24 months. All KOOS subscores improved between baseline and 24 months.Discussion: Clinical results of this study demonstrate clinically and statistically significant improvements of pain and function scores (VAS, IKDC, and all KOOS subscales except sport), at the 6 months follow-up and on all clinical outcomes at the 2-year follow-up. The Actifit (R) scaffold is safe and effective in treating lateral meniscus defects. (C) 2013 Elsevier Masson SAS. All rights reserved.