Nascent Connections: R-Loops and Chromatin Patterning.
Nascent Connections: R-Loops and Chromatin Patterning.
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DOI：
10.1016/j.tig.2016.10.002
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Chédin F
中科院分区：
文献类型：
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作者：
Chédin F
长链非编码RNA等RNA分子在调节基因表达、染色体结构和染色质修饰状态方面发挥着关键作用。最近的研究表明，RNA还可能通过形成共转录r环结构，使新生转录物与其DNA模板相互作用，从而影响基因表达和染色质模式。在哺乳动物基因组中，特定的、保守的、热点上的r环形成发生在数千个基因上，代表了哺乳动物染色质的一个重要的动态特征。在这里，主要集中在哺乳动物系统，我描述了积累连接和可能的机制连接r环形成和染色质模式。还讨论了异常r环对病理条件的可能贡献。
RNA molecules such as long non-coding RNAs play critical roles in regulating gene expression, chromosome architecture, and the modification states of chromatin. Recent developments suggest that RNA may also influence gene expression and chromatin patterns through the interaction of nascent transcripts with their DNA template via the formation of co-transcriptional R-loop structures. R-loop formation over specific, conserved, hotspots occurs at thousands of genes in mammalian genomes and represents an important and dynamic feature of mammalian chromatin. Here, focusing primarily on mammalian systems, I describe the accumulating connections and possible mechanisms linking R-loop formation and chromatin patterning. The possible contribution of aberrant R-loops to pathological conditions is also discussed.