Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromso Study
Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromso Study
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DOI：
10.1111/j.1365-2796.2006.01652.x
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发表时间：
2006-07-01
影响因子：
11.1
通讯作者：
Figenschau, Y.
中科院分区：
文献类型：
--
作者：
Iqbal, A.;Jorde, R.;Figenschau, Y.
客观的。评估血清促甲状腺激素（TSH）与血脂之间的关系。设计。横断面流行病学研究、巢式病例对照研究和安慰剂对照双盲干预研究。方法。在第 5 次特罗姆瑟研究中，测量了血清 TSH、总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL-C) 和低密度脂蛋白胆固醇 (LDL-C)。对亚临床甲状腺功能减退症 (SHT) 受试者和匹配的对照组进行重新检查，并测量载脂蛋白 A1 (Apo A1) 和载脂蛋白 B (Apo B)。患有 SHT 的受试者被纳入一项为期 1 年的补充甲状腺素的干预研究。结果。第 5 次特罗姆瑟研究共纳入 5143 名受试者。男女血清 TSH 水平与血清 TC 和 LDL-C 水平均呈显着正相关。然而，在女性中，调整年龄和体重指数后，这一结果并未达到统计学显着性。与 145 名对照者相比，84 名 SHT 受试者的血清 LDL-C 显着升高，Apo A1 水平显着降低，并且 SHT 女性中 TC 水平也显着升高。在干预研究中（32 名受试者给予甲状腺素，32 名受试者给予安慰剂），我们观察到甲状腺素药物治疗后 Apo B 水平显着降低。在研究结束时血清TSH水平在0.2-2.0 mIU L-1范围内的患者中，血清TC和LDL-C水平也显着降低。结论。血清 TSH 水平与 TC 和 LDL-C 水平呈正相关。 SHT 患者接受甲状腺素治疗后，这些脂质水平会降低。
Objective. To evaluate the relation between serum thyroid-stimulating hormone (TSH) and lipids.Design. Cross-sectional epidemiological study, nested case-control study, and a placebo-controlled double-blind intervention study.Methods. In the 5th Tromso study serum TSH, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured. Subjects with subclinical hypothyroidism (SHT) and a matching control group were re-examined and apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were also measured. Subjects with SHT were included in an intervention study with thyroxine supplementation for 1 year.Results. A total of 5143 subjects from the 5th Tromso study were included. A significant and positive correlation between serum TSH levels and serum TC and LDL-C levels were found in both genders. However, in the females this did not reach statistical significance after adjusting for age and BMI. The serum LDL-C were significantly higher and the Apo A1 levels significantly lower in 84 SHT subjects compared with 145 controls, and in the SHT females the TC levels were also significantly elevated. In the intervention study (32 subjects given thyroxine and 32 subjects given placebo), we observed a significant reduction in the Apo B levels after thyroxine medication. In those that at the end of the study had serum TSH levels in the range 0.2-2.0 mIU L-1, the serum TC and LDL-C levels were also significantly reduced.Conclusions. There is a positive association between serum TSH levels and TC and LDL-C levels. These lipid levels are reduced with thyroxine treatment in subjects with SHT.