Guiding Neuronal Cell Migrations
Guiding Neuronal Cell Migrations
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DOI：
10.1101/cshperspect.a001834
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发表时间：
2010-02-01
影响因子：
7.2
通讯作者：
Tsai, Li-Huei
中科院分区：
文献类型：
--
作者：
Marin, Oscar;Valiente, Manuel;Tsai, Li-Huei
神经元迁移是大脑布线的基本机制之一，沿着轴突引导。与其他器官一样，神经系统已经获得了在大小和复杂性上都增长的能力，通过使用迁移作为一种策略，将来自不同来源的细胞类型定位到特定的坐标中，从而允许产生脑回路。迁移神经元的引导与轴突引导有许多共同的特征，从底物的使用到调节趋化性的特定线索。然而，这两个过程的细胞生物学存在重要差异。最明显的例子是核分裂，这是迁移的一个重要组成部分，需要整合在细胞的指导下。也许更令人惊讶的是，迁移细胞的引导过程的反应的细胞机制可能是不同的，至少对于一些神经元群体的生长锥转向参与。
Neuronal migration is, along with axon guidance, one of the fundamental mechanisms underlying the wiring of the brain. As other organs, the nervous system has acquired the ability to grow both in size and complexity by using migration as a strategy to position cell types from different origins into specific coordinates, allowing for the generation of brain circuitries. Guidance of migrating neurons shares many features with axon guidance, from the use of substrates to the specific cues regulating chemotaxis. There are, however, important differences in the cell biology of these two processes. The most evident case is nucleokinesis, which is an essential component of migration that needs to be integrated within the guidance of the cell. Perhaps more surprisingly, the cellular mechanisms underlying the response of the leading process of migrating cells to guidance cues might be different to those involved in growth cone steering, at least for some neuronal populations.