Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival
Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival
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DOI：
10.1007/s10549-010-0998-5
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发表时间：
2010-08-01
影响因子：
3.8
通讯作者：
Lee, Eun Sook
中科院分区：
文献类型：
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作者：
Lee, Jung Ah;Kim, Kwan-Il;Lee, Eun Sook
我们使用韩国乳腺癌协会注册计划数据分析了乳腺癌亚型，以比较三阴性乳腺癌 (TNBC) 的临床特征和预后。 26,767 名乳腺癌患者被分为四组：Luminal A（ER+ 和/或 PR+、HER2-）、Luminal B（ER+ 和/或 PR+ HER2+）、HER2+（ER-、PR-、HER2+）和三阴性（ER-、PR-、HER2-）。评估临床病理因素。 Luminal A 亚型（14,437 名患者，53.9%）是我们研究中最大的亚型。与 Luminal A 亚型相比，TNBC 与更年轻的年龄、更具侵袭性的特征以及较差的总体生存率和乳腺癌特异性生存率相关。 TNBC 亚型的危险率在 24 个月时达到峰值，但 60 个月后，风险与 Luminal A 亚型相似。较高的 T、N 分期和组织学分级以及淋巴和血管侵犯表明 TNBC 患者预后较差，但在多变量分析中仅组织学分级和 ki-67 状态相关。 Luminal A 亚型的年轻年龄与不良预后相关，但 TNBC 亚型的年龄与预后无关。在5,586名TNBC患者中，282名患者（7.11%）在诊断后3年内死亡。多变量分析表明，T 和 N 分期和分级与预后显着相关。 TNBC亚型的特点是年龄较小，预后较差。然而，年龄较小与预后无关，死亡风险降低至 Luminal A 亚型，众所周知，几年后该亚型的预后最好。
We analyzed breast cancer subtypes using Korean Breast Cancer Society Registration Program data to compare clinical features and prognosis for triple-negative breast cancer (TNBC). A cohort of 26,767 breast cancer patients were divided in four groups: luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+ HER2+), HER2+ (ER-, PR-, HER2+), and triple-negative (ER-, PR-, HER2-). Clinicopathologic factors were evaluated. The luminal A (14,437 patients, 53.9%) subtype was the largest in our study. Compared with luminal A subtype, TNBC correlated with younger age, more aggressive characteristics and poor overall survival and breast cancer-specific survival. The hazard rate showed a peak at 24 months for the TNBC subtype, but after 60 months, risk was similar to that of the luminal A subtype. Higher T, N stage and histologic grade, and lymphatic and vascular invasion showed poor prognosis in TNBC patients, but on multivariate analysis only histologic grade and ki-67 status were related. Young age was related to poor prognosis in the luminal A subtype, however, age was not related to prognosis in the TNBC subtype. Of the 5,586 TNBC patients, 282 patients (7.11%) expired within 3 years of diagnosis. T and N stage and grade were significantly associated with prognosis on multivariate analysis. TNBC subtype is characterized by younger age with poorer outcome. However, younger age is not related to prognosis, and mortality risk decreases to that of the luminal A subtype, which is known to have the best prognosis after a few years.