Effects of poor sleep quality on brain functional connectivity revealed by wavelet-based coherence analysis using NIRS methods in elderly subjects
Effects of poor sleep quality on brain functional connectivity revealed by wavelet-based coherence analysis using NIRS methods in elderly subjects
复制标题
使用 NIRS 方法进行基于小波的相干性分析揭示了老年受试者睡眠质量差对大脑功能连接的影响
DOI：
10.1016/j.neulet.2018.01.026
复制
发表时间：
2018-03-06
影响因子：
2.5
通讯作者：
Li, Jianfeng
中科院分区：
文献类型：
--
作者：
Bu, Lingguo;Wang, Dawei;Li, Jianfeng
目的：睡眠质量差是老年人普遍存在的问题，睡眠质量差通常与认知控制障碍有关。然而，睡眠和老年人行为之间的联系的大脑功能机制仍然是难以捉摸的。采用近红外光谱法（NIRS）测量血氧浓度变化（Delta [HbO（2）]）的小波相位相干性（WPCO）和小波幅度（WA），探讨睡眠质量差对低频神经振荡的影响。连续记录15名睡眠质量差的老年人（PSQ组）和14名健康老年人（对照组）在静息状态和任务状态下的前额叶、感觉运动皮层和枕叶近红外光谱信号。在低频（0.01-0.08 Hz）下计算WPCO和WA值。采用Pearson相关分析法分别评价双侧前额叶WPCO、左前额叶WA（LPFC）、右前额叶WA（RPFC）、F-1评分和PSQI评分之间的相关程度。与对照组相比，PSQ组的WA显著高于对照组，并且在静息状态下也显著高于任务状态。PSQ组在执行1-back任务时的F-1评分显著低于对照组。PSQ组PSQI评分与WPCO值呈负相关。WA值的LPFC和RFFC表现出正相关与PSQI scores.Conclusions：总的来说，这些结果表明，睡眠不佳减少相位同步，这可能有助于减少样本人群之间的认知功能。
Objective: Poor sleep quality, which is typically related to impairments in cognitive control, is pervasive among the elderly. However, the brain function mechanisms underlying the association between sleep and elderly behavior remain elusive. This study aims to assess the effects of poor sleep quality on low-frequency neural oscillations based on the wavelet phase coherence (WPCO) and wavelet amplitude (WA) of oxyhemoglobin concentration changes (Delta [HbO(2)]) measured through near-infrared spectroscopy (NIRS) method.Methods: Subjective sleep quality was measured through the Pittsburgh Sleep Quality Index (PSQI). Continuously recorded NIRS signals from the prefrontal cortex, sensorimotor cortical, and occipital lobes of 15 poor-sleep-quality elderly subjects (PSQ group) as well as 14 healthy elderly subjects (control group) in the resting and task states. The WPCO and WA values were calculated in low frequency (0.01-0.08 Hz). Pearson correlation analysis was used to assess the respective degrees of correlation between the WPCO of bilateral prefrontal lobes, WA of left prefrontal cortex (LPFC), WA of right prefrontal cortex (RPFC), F-1 scores, and PSQI scores, respectively.Results: The WPCO values were significantly lower in the PSQ group than in the control group (p < 0.05). Compared with the control group, the WA was significantly higher in the PSQ group and was also significantly higher in the resting state than in the task state. The F-1 scores were significantly lower in the PSQ group when performing 1-back task. In the PSQ group, the correlation analysis showed the negative correlation between the PSQI scores and WPCO values. The WA values of LPFC and RFFC exhibited positive correlations with the PSQI scores.Conclusions: Collectively, these results suggest that poor sleep reduces phase synchronization, which may contribute to the diminished cognitive functions among the sample population.