Role of Autophagy in HIV Pathogenesis and Drug Abuse.
Role of Autophagy in HIV Pathogenesis and Drug Abuse.
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DOI：
10.1007/s12035-016-0118-6
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发表时间：
2017-10
影响因子：
5.1
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Cao L;Glazyrin A;Kumar S;Kumar A
自噬是一个高度调控的过程，在剥夺条件下，过量的细胞质物质被捕获和降解。自噬清除入侵微生物的独特性质使其成为各种临床情况下重要的细胞防御机制。近年来，人们越来越清楚自噬广泛参与HIV-1的病理学过程。为了确保病毒的存活，HIV-1病毒蛋白调节并利用自噬途径，使病毒的生物合成最大化。与此同时，滥用甲基苯丙胺、可卡因、吗啡和酒精等非法药物被认为是 HIV-1 感染和进展的重要危险因素。在药物引起的毒性过程中，多种细胞类型的自噬活性已被证明发生了改变。在此，我们回顾了有关自噬、HIV-1 和药物滥用之间相互作用的最新文献，并讨论了自噬在 HIV-1 发病机制中在同时接触非法药物中的复杂作用。
Autophagy is a highly regulated process in which excessive cytoplasmic materials are captured and degraded during deprivation conditions. The unique nature of autophagy that clears invasive microorganisms has made it an important cellular defense mechanism in a variety of clinical situations. In recent years, it has become increasingly clear that autophagy is extensively involved in the pathology of HIV-1. To ensure survival of the virus, HIV-1 viral proteins modulate and utilize autophagy pathway so that biosynthesis of the virus is maximized. At the same time, the abuse of illicit drugs such as methamphetamine, cocaine, morphine, and alcohol is thought to be a significant risk factor for the acquirement and progression of HIV-1. During drug-induced toxicity, autophagic activity has been proved to be altered in various cell types. Here we review the current literature on the interaction between autophagy, HIV-1, and drug abuse, and discuss the complex role of autophagy during HIV-1 pathogenesis in co-exposure to illicit drugs.