MEAL-FREQUENCY EFFECTS ON PLASMA-HORMONE CONCENTRATIONS AND CHOLESTEROL-SYNTHESIS IN HUMANS
MEAL-FREQUENCY EFFECTS ON PLASMA-HORMONE CONCENTRATIONS AND CHOLESTEROL-SYNTHESIS IN HUMANS
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DOI：
10.1093/ajcn/57.6.868
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发表时间：
1993-06-01
影响因子：
7.1
通讯作者：
PEDERSON, RA
中科院分区：
文献类型：
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作者：
JONES, PJH;LEITCH, CA;PEDERSON, RA
为了研究餐频对循环激素浓度和胆固醇合成的影响，男性受试者在3天内食用6顿均匀间隔（ES）或3顿昼夜（DI）的流质饮食。在第2天给予氧化氘，并在第2天和第3天每4小时采集一次血样，以测量血浆胆固醇、葡萄糖、胰岛素和葡萄糖依赖性促胰岛素多肽（GIP）浓度和胆固醇合成。通过使用约束和非约束曲线拟合模型从氘掺入血浆游离胆固醇中确定胆固醇合成。ES组和DI组血浆总胆固醇浓度均降低（P < 0.05）。与DI组相比，ES组的胰岛素（P < 0.05）和GIP（P < 0.001）浓度较低。当使用约束模型（分别为0.050 +/- 0.002 vs 0.075 +/- 0.005池/d）和非约束模型（分别为0.072 +/-0.005 vs 0.119 +/- 0.011池/d）测定时，ES组与DI组相比胆固醇合成减少（P < 0.01）。这些数据表明，膳食频率依赖性控制胆固醇的生成通过尿道介导的机制。
To examine meal-frequency effects on circulating hormone concentrations and cholesterol synthesis, male subjects consumed liquid diets given as either six evenly spaced (ES) or three diurnal (DI) meals over 3 d. Deuterium oxide was given on day 2 and blood sampled every 4 h over days 2 and 3 to measure plasma cholesterol, glucose, insulin, and glucose-dependent insulinotropic polypeptide (GIP) concentrations and cholesterol synthesis. Cholesterol synthesis was determined from deuterium incorporation into plasma free cholesterol by using constrained and unconstrained curve-fit models. Plasma total cholesterol concentrations decreased in both ES and DI groups (P < 0.05). The ES group had lower insulin (P < 0.05) and GIP (P < 0.001) concentrations compared with the DI group. Cholesterol synthesis was reduced (P < 0.01) in the ES vs the DI group when determined by using constrained (0.050 +/- 0.002 vs 0.075 +/- 0.005 pools/d, respectively) and unconstrained (0.072 +/- 0.005 vs 0.119 +/- 0.011 pools/d, respectively) models. These data suggest meal frequency-dependent control of cholestero-genesis via hormonally mediated mechanisms.