INDUCTION OF SELF-TOLERANCE IN MATURE PERIPHERAL LYMPHOCYTES-B
INDUCTION OF SELF-TOLERANCE IN MATURE PERIPHERAL LYMPHOCYTES-B
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DOI：
10.1038/342385a0
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发表时间：
1989-11-23
期刊：
影响因子：
64.8
通讯作者：
BASTEN, A
中科院分区：
文献类型：
--
作者：
GOODNOW, CC;CROSBIE, J;BASTEN, A
在转基因小鼠中，淋巴滤泡中的成熟外周B淋巴细胞与未成熟B细胞一样，如果自身抗原的受体占有率超过临界阈值，则可耐受自身抗原。B细胞的耐受状态与膜IgM而不是IgD抗原受体的下调密切相关。在非转基因小鼠的滤泡B细胞亚群中发生抗原受体表达的相同变化，表明克隆沉默的自身反应细胞在外周B细胞库中很常见。
In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by self-antigen exceeds a critical threshold. The tolerant state of the B cell is closely correlated with down-regulation of membrane IgM but not IgD antigen-receptors. Identical changes in antigen-receptor expression occur in a subset of follicular B cells in nontransgenic mice, suggesting that clonally silenced self-reactive cells are common in the peripheral B-cell repertoire.