Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt-Jakob disease
Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt-Jakob disease
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DOI：
10.1159/000107082
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Eguchi, Katsumi
中科院分区：
文献类型：
--
作者：
Satoh, Katsuya;Shirabe, Susumu;Eguchi, Katsumi
背景资料：近年来，我们开始怀疑脑电图上观察到的周期性尖波复合波和脑脊液（CSF）中14-3-3蛋白的检测作为Creutzfeldt-Jakob病（CJD）诊断标准的有效性。磁共振弥散加权成像（DWI）和脑脊液中总tau蛋白（t-tau）的检测可能是更敏感的诊断标准。研究方法：在44名CJD患者中，我们选择了21名患有早期CJD的受试者，早期CJD定义为发病后6周内的病例。比较DWI、脑电图及脑脊液中t-tau蛋白、14-3-3蛋白、神经元特异性烯醇化酶（NSE）、S-100 b蛋白作为早期CJD诊断指标的敏感性。结果如下：NSE、S-100 b蛋白、t-tau蛋白和14-3-3蛋白的阳性率分别为57.1%、4.8%、95.2%和76.2%。此外，DWI用于阳性识别这些病例的90.5%。结论：T-tau蛋白是CJD最敏感的诊断指标。此外，本研究的数据显示，t-tau蛋白检测结合DWI可识别98%的早期病例，这些检测应作为CJD的诊断标准。
Background: We have recently begun to doubt the effectiveness of periodic sharp wave complexes observed on electroencephalographs and the detection of 14-3-3 protein in cerebrospinal fluid (CSF) as diagnostic criteria for Creutzfeldt-Jakob disease (CJD). Diffusion-weighted magnetic resonance imaging (DWI) and the detection of total tau (t-tau) protein in CSF may be more sensitive diagnostic criteria. Methods: Among 44 CJD patients, we selected 21 subjects that suffered from early-stage CJD, which was defined as cases in the 6 weeks following the onset of the disease. The sensitivities of DWI and electroencephalographs, as well as those of t-tau protein, 14-3-3 protein, neuron-specific enolase (NSE), and S-100b protein in CSF were compared as diagnostic markers for early-stage CJD. Results: NSE, S-100b protein, t-tau protein, and 14-3-3 protein were detected in the samples from 57.1, 4.8, 95.2, and 76.2% of the 21 earlystage CJD patients, respectively. Additionally, DWI was used to positively identify 90.5% of these cases. Conclusion: We concluded that t-tau protein was the most sensitive of the diagnostic markers for CJD. Moreover, the data in this study showed that detection of t-tau protein combined with DWI identified 98% of the early-stage cases, and these tests should be included as diagnostic criteria for CJD.