A total score for the CERAD neuropsychological battery
A total score for the CERAD neuropsychological battery
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DOI：
10.1212/01.wnl.0000167607.63000.38
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发表时间：
2005-07-12
期刊：
影响因子：
9.9
通讯作者：
Cullum, CM
中科院分区：
文献类型：
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作者：
Chandler, MJ;Lacritz, LH;Cullum, CM
目的：为建立阿尔茨海默病登记研究联盟（CERAD）神经心理成套测验制定总分或综合评分。方法：通过将各个CERAD子测试（不包括简易精神状态检查[MMSE]）的评分汇总为总复合评分（最高评分= 100），获得CERAD总评分。使用CERAD登记数据库中的正常对照（NC; n = 424）和AD患者（n = 835）构建总分制表方法。在轻度AD（n = 95）、轻度认知障碍（MCI; n = 60）和NC（n = 95）受试者的独立样本中进一步检验总分的效用。结果：在CERAD登记研究中，CERAD总分在区分NC和AD受试者方面具有高度准确性。观察年龄、性别和教育程度的影响，并通过多元回归分析得出人口统计学校正分数。经人口统计学校正的CERAD总分在所有样本中显示出出色的重测可靠性（r = 0.95），并且与混合AD和NC样本中的MMSE（r = 0.89）和临床痴呆评定量表（r = 0.83）以及AD样本中的祝福痴呆评定量表高度相关（r =-0.40）。CERAD总分在区分NC、MCI和AD受试者的独立样本方面高度准确。结论：研究结果为阿尔茨海默病登记协会（CERAD）总分的有效性提供了支持，该总分可与规范性数据一起沿着使用，以提供CERAD神经心理电池的认知功能总体水平指数。
Objective: To develop a total or composite score for the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. Method: CERAD total scores were obtained by summing scores from the individual CERAD subtests ( excluding the Mini-Mental State Examination [MMSE]) into a total composite ( maximum score = 100). The method of tabulating the total score was constructed using normal controls (NCs; n = 424) and patients with AD ( n = 835) from the CERAD registry database. The utility of the total score was further tested in independent samples of mild AD ( n = 95), mild cognitive impairment (MCI; n = 60), and NC ( n = 95) subjects. Results: The CERAD total score was highly accurate in differentiating NC and AD subjects in the CERAD registry. Age, gender, and education effects were observed, and demographic correction scores were derived through multiple regression analysis. Demographically corrected CERAD total scores showed excellent test-retest reliability across samples ( r = 0.95) and were highly correlated with the MMSE ( r = 0.89) and Clinical Dementia Rating Scale ( r = 0.83) in mixed AD and NC samples and with the Blessed Dementia Rating Scale in an AD sample ( r = - 0.40). The CERAD total score was highly accurate in differentiating independent samples of NC, MCI, and AD subjects. Conclusion: Results provide support for the validity of a Consortium to Establish a Registry for Alzheimer's Disease (CERAD) total score that can be used along with the normative data to provide an index of overall level of cognitive functioning from the CERAD neuropsychological battery.