Deep brain stimulation of the subthalamic nucleus: histological verification and 9.4-T MRI correlation
Deep brain stimulation of the subthalamic nucleus: histological verification and 9.4-T MRI correlation
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DOI：
10.1007/s00701-015-2599-x
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发表时间：
2015-12-01
影响因子：
2.4
通讯作者：
Zrinzo, Ludvic
中科院分区：
文献类型：
--
作者：
Al-Helli, Othman;Thomas, David L.;Zrinzo, Ludvic
使用 MRI 引导和 MRI 验证的技术（无需微电极记录）对丘脑底核 (STN) 进行深部脑刺激 (DBS)，对于帕金森病 (PD) 患者来说是一种有效且安全的手术治疗方法。为了使用尸检组织学和 9.4 T 的高场 MRI 来评估 MRI 引导、MRI 验证的 STN DBS 后引线放置的解剖学准确性。我们对患者的大脑进行了尸检分析他们使用 9.4-T MRI 和组织学进行了 MRI 引导、经 MRI 验证的 PD STN DBS。死亡后，取回大脑，并使用 9.4 T 的高场 MRI 检查包括电极轨迹直至中脑的块并进行组织学分析。高场 MRI 图像和相应的组织学检查显示每个电极轨迹都在预期目标区域内结束，并且 DBS 不会造成明显的神经实质组织损伤。这项研究支持 MRI 引导和 MRI 验证的 STN DBS 方法的解剖学准确性。
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using an MRI-guided and MRI-verified technique without microelectrode recording is an effective and safe surgical treatment for patients with Parkinson's disease (PD).To assess the anatomical accuracy of lead placement after MRI-guided, MRI-verified STN DBS using post-mortem histology and high-field MRI at 9.4 T.We conducted post-mortem analysis of a patient's brain who had had MRI-guided, MRI-verified STN DBS for PD, using 9.4-T MRI and histology. After death, the brain was retrieved and a block including the electrode tracks down to the mesencephalon was examined with high-field MRI at 9.4 T and histological analysis.High-field MRI images and corresponding histological examination showed that each electrode track ended within the intended target area, and that DBS did not cause significant neuroparenchymal tissue damage.This study supports the anatomical accuracy of the MRI-guided and MRI-verified method of STN DBS.