Effects of Twenty Days of the Ketogenic Diet on Metabolic and Respiratory Parameters in Healthy Subjects
Effects of Twenty Days of the Ketogenic Diet on Metabolic and Respiratory Parameters in Healthy Subjects
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DOI：
10.1007/s00408-015-9806-7
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发表时间：
2015-12-01
期刊：
影响因子：
5
通讯作者：
Antonio, Paoli
中科院分区：
文献类型：
--
作者：
Alessandro, Rubini;Gerardo, Bosco;Antonio, Paoli
目的研究生酮饮食（KD）对健康受试者体重减轻、代谢和呼吸参数的影响。KD组遵循生酮饮食20天（KD t（0）-t（20）），然后转换为低碳水化合物，无生酮饮食20天（KD t（20）-t（40）），最后再接受地中海饮食（MD）2个月（KD t（40）-t（2 m））。MD组接受MD治疗20天（MD t（0）-t（20）），然后在接下来的20天内接受1400 kcal的MD治疗（MD t（20）-t（40）），并在MD治疗2个月后完成研究（MD t（40）-t（2 m））。体重、体脂、呼吸频率和呼吸气体参数（包括呼吸交换率（RER）和二氧化碳潮气末分压（PETCO 2）、摄氧量（VO 2）、二氧化碳产生量（VCO 2），和静息能量消耗（REE）。KD组在20和40天后观察到RER（p < 0.05），而MD组未观察到。在KD组中，观察到二氧化碳排出量和PETCO 2均显著降低，但VO 2、VCO 2和REE无显著变化。虽然这两种饮食显着降低体脂量，KD饮食整体证明有较高的脂肪损失的百分比与MD diet.Conclusion KD可能会显着降低二氧化碳的身体存储，这可能在理论上是有益的二氧化碳动脉分压增加，由于呼吸功能不全或衰竭的患者。
Purpose The effects of the ketogenic diet (KD) on weight loss, metabolic, and respiratory parameters were investigated in healthy subjects.Methods Thirty-two healthy subjects were randomized into two groups. The KD group followed a ketogenic diet for 20 days (KD t (0)-t (20)), then switched to a low-carbohydrate, no-ketogenic diet for 20 days (KD t (20)-t (40)), and finally was on a Mediterranean diet (MD) for 2 more months (KD t (40)-t (2m)). The MD group followed a MD for 20 days (MD t (0)-t (20)), then followed a MD of 1400 kcal over the next 20 days (MD t (20)-t (40)), and completed the study with the MD for 2 months (MD t (40)-t (2m)). Body weight, body fat, respiratory rate, and respiratory gas parameters (including respiratory exchange ratio (RER) and carbon dioxide end-tidal partial pressure (PETCO2), oxygen uptake (VO2), carbon dioxide production (VCO2), and resting energy expenditure (REE)) were measured at each point.Results A significant decrease (p < 0.05) in RER was observed after 20 and 40 days in the KD group, but not in the MD group. In the KD group, significant reductions were observed for both carbon dioxide output and PETCO2, however, there was no significant change in VO2, VCO2, and REE. While both diets significantly decreased body fat mass, the KD diet overall proved to have a higher percentage of fat loss versus the MD diet.Conclusion The KD may significantly decrease carbon dioxide body stores, which may theoretically be beneficial for patients with increased carbon dioxide arterial partial pressure due to respiratory insufficiency or failure.