Disruption of parental-specific expression of imprinted genes in uniparental fetuses
Disruption of parental-specific expression of imprinted genes in uniparental fetuses
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DOI：
10.1016/j.febslet.2006.08.087
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发表时间：
2006-10-02
期刊：
影响因子：
3.5
通讯作者：
Kono, Tomohiro
中科院分区：
文献类型：
--
作者：
Ogawa, Hidehiko;Wu, Qiong;Kono, Tomohiro
在哺乳动物中，印迹基因表现出依赖于亲本来源的表达，其基于称为基因组印迹（GI）的表观遗传修饰，其在精子发生或卵子发生期间独立地建立。由于GI，单亲胎儿从未发育到足月。为了确定这种印记基因的表达是否在单亲小鼠胎儿中保持，我们分析了20个父系和11个母系表达的基因在雄激素和孤雌生殖胎儿中的表达。每种类型的四个基因在两组胎儿中表达。此外，定量分析表明，表达水平偏离了一些印迹基因的假定水平。这些结果表明，在父亲和母亲等位基因之间反式作用的机制参与了一些印记基因的适当表达。(c)2006年由Elsevier B.V.代表欧洲生物化学学会联合会出版。
In mammals, imprinted genes show parental origin-dependent expression based on epigenetic modifications called genomic imprinting (GI), which are established independently during spermatogenesis or oogenesis. Due to GI, uniparental fetuses never develop to term. To determine whether such expression of imprinted genes is maintained in uniparental mouse fetuses, we analyzed the expression of 20 paternally and 11 maternally expressed genes in androgenetic and parthenogenetic fetuses. Four genes of each type were expressed in both groups of fetuses. Furthermore, quantitative analysis showed that expression levels deviated from the presumed levels for some imprinted genes. These results suggest that mechanisms acting in trans between paternal and maternal alleles are involved in the appropriate expression of some imprinted genes. (c) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.