Accuracy of Self-Reported HIV Status Among African Men and Transgender Women Who Have Sex with Men Who were Screened for Participation in a Research Study: HPTN 075.

Accuracy of Self-Reported HIV Status Among African Men and Transgender Women Who Have Sex with Men Who were Screened for Participation in a Research Study: HPTN 075.
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DOI:
10.1007/s10461-018-2231-1
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发表时间:
2019-01
期刊:
影响因子:
4.4
通讯作者:
Eshleman SH
Eshleman SH
中科院分区:
医学2区
文献类型:
--
作者:
Fogel JM;Sandfort T;Zhang Y;Guo X;Clarke W;Breaud A;Cummings V;Hamilton EL;Ogendo A;Kayange N;Panchia R;Dominguez K;Chen YQ;Eshleman SH

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研究中的一些HIV感染者可能选择不向研究人员透露其HIV状态的知识。我们评估了与男性发生性关系的非洲男性和跨性别女性自我报告的艾滋病毒状况的准确性,并对他们进行了研究筛选。183名艾滋病毒感染者中有67人报告了先前的艾滋病毒诊断。其余116名参与者的样本进行了抗逆转录病毒(ARV)药物检测。116名参与者中有36人检测到抗逆转录病毒药物,表明他们正在接受抗逆转录病毒治疗;这些参与者被归类为先前根据抗逆转录病毒药物检测诊断的患者。在被归类为既往诊断的参与者中,既往HIV诊断的披露在研究中心之间存在差异(p=0.006),并且在仅报告与男性发生性关系的参与者中更为常见(p=0.002)。除了自我报告外,抗逆转录病毒药物检测提高了识别先前诊断为艾滋病毒的个人的准确性。
Some HIV-infected individuals in research studies may choose not to disclose knowledge of their HIV status to study staff. We evaluated the accuracy of self-reported HIV status among African men and transgender women who have sex with men and who were screened for a research study. Sixty-seven of 183 HIV-infected participants reported a prior HIV diagnosis. Samples from the remaining 116 participants were tested for antiretroviral (ARV) drugs. Thirty-six of the 116 participants had ARV drugs detected, indicating that they were on antiretroviral treatment; these participants were classified as previously diagnosed based on ARV drug testing. Among participants classified as previously diagnosed, disclosure of a prior HIV diagnosis varied among study sites (p=0.006) and was more common among those who reported having sex with men only (p=0.002). ARV drug testing in addition to self-report improves the accuracy for identifying individuals with a prior HIV diagnosis.
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