Mayaro virus: imported cases of human infection in São Paulo State, Brazil
Mayaro virus: imported cases of human infection in São Paulo State, Brazil
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DOI：
10.1590/s0036-46652007000400005
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发表时间：
2007-08-01
期刊：
影响因子：
--
通讯作者：
Rocco, Iray M.
中科院分区：
文献类型：
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作者：
Coimbra, Terezinha Lisieux M.;Santos, Cecília L. S.;Rocco, Iray M.
Mayaro virus (MAYV) is an arbovirus (Togaviridae: Alphavirus,) enzootic in tropical South America and maintained in a,vlvansylvane involving, wild vertebrates and Haemagogus mosquitoes. MAYV cases occur sporadically in persons with a history of recent activities inside or around forests. This paper reports three cases of MAYV fever detected in men infected in Camapua. MS, Brazil. Serum samples collected at four days and two months after the onset of the symptoms and examined by hemagglutination inhibition test, revealed monotypic seroconversion to MAYV. Isolation of tire virus was obtained from one of the samples by inoculation of tire first blood samples into newborn mice. A suspension of the infected mouse brain was inoculated into C6/36 cells culture and the virus was identified by indirect immunofluorescent assay with alphavirus polyclonal antibodies. RT-PCR, performed with RNA extracted from the supernatant of C6/36 infected cells in the presence of alphavirus generic primers as well as specific MAYV primers, confirmed these result,,,. The reported cases illustrate the importance of laboratory confirmation in establishing a correct diagnosis. Clinical symptoms are not always indicative of a disease caused by in arbovirus. Also MAYV causes febrile illness, which may be mistaken for dengue.
