Linkage between X‐chromosome markers and manic‐depressive illness
Linkage between X‐chromosome markers and manic‐depressive illness
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X染色体标记与躁狂抑郁症之间的联系
DOI：
10.1111/j.1600-0447.1984.tb01210.x
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发表时间：
1984
影响因子：
6.7
通讯作者：
G. Corsini
中科院分区：
文献类型：
--
作者：
M. Zompo;A. Bocchetta;L. Goldin;G. Corsini
摘要：对在卡利亚里大学临床药理学研究所锂诊所接受治疗的躁狂抑郁症患者的家系进行了评估，以了解主要情感疾病与 X 染色体的 protan-deulan-glucose-6-phosphatc-dehydrogenase 区域之间的联系。使用多代模型并考虑年龄依赖性外显率，发现、调查和分析了两个信息丰富的谱系。结果与重大情感疾病中 X 连锁的假设一致。
ABSTRACT– Pedigrees of manic‐depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan‐deulan‐glucose‐6‐phosphatc‐dehydrogenase region of the X‐chromosome. Two informative pedigrees were found, investigated and analyzed for linkage using a multigenerational model and considering age‐dependent penetrance. The results are consistent with the hypothesis of X‐linkage in major affective illness.
影响因子：
4.8
作者：
MANNUZZA, S;FYER, AJ;ENDICOTT, J
通讯作者：
ENDICOTT, J